Temovate 0.05% (Ointment)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clobetasol propionate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Psoriasis (excluding widespread plaque psoriasis)
- Recalcitrant dermatoses
- Lichen planus
- Discoid lupus erythematosus
- Other skin conditions which do not respond satisfactorily to less potent steroids
Composition
- Clobetasol Propionate Cream
- Clobetasol Propionate Ointment
- Clobetasol Propionate Scalp Application
- Clobetasol Propionate Shampoo
- Clobetasol Propionate Lotion
- Clobetasol Propionate Spray
Pharmacology
Very potent topical corticosteroid with anti-inflammatory, antipruritic, and vasoconstrictive properties
Dosage
- Adults, elderly and children over 1 year: Apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily
- Super-high potency topical corticosteroids; treatment should be limited to 2 consecutive weeks with a maximum weekly dose of 50 gm/week
- Apply required quantity of spray of once or twice daily to the affected areas of the scalp
- Shampoo should be applied to the dry scalp once a day to the affected areas only
Administration
Cutaneous. Creams are especially appropriate for moist or weeping surfaces, while ointments are appropriate for dry, lichenified, or scaly lesions
Interaction
Co-administered drugs that can inhibit CYP3A4 have been shown to inhibit the metabolism of corticosteroids
Contraindications
- Rosacea, acne vulgaris and perioral dermatitis
- Hypersensitivity to the preparation
- Primary cutaneous viral infections
- Dermatoses in children under one year of age
Side Effects
- Prolonged use of large amounts or treatment of extensive areas can result in sufficient systemic absorption to produce the features of hypercorticism
- Local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels
- Exacerbation of symptoms may occur
Pregnancy & Lactation
Limited data from the use of Clobetasol Propionate cream in pregnant women; caution should be exercised when administered to a nursing woman
Precautions & Warnings
- Long-term continuous topical therapy should be avoided, particularly in infants and children
- Atrophic changes may occur after prolonged treatment with potent topical corticosteroids
- Care is needed to ensure that the preparation does not enter the eye
Use in Special Populations
Long-term continuous topical corticosteroid therapy should be avoided in infants and children under 12 years of age
Overdose Effects
Acute overdosage is very unlikely to occur, chronic over-dosage may lead to hypercortisolism
Therapeutic Class
Other Topical corticosteroids
Storage Conditions
Keep below 30°C, protected from light and moisture; do not freeze