Doxiflo 200 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Biopharma limited |
| Also available as |
Title
Doxiflo 400mg Tablet
Categories
- Medicine
- Bronchodilator
- Methyl Xanthine Derivative
Description
Doxiflo is a bronchodilator used to treat bronchial asthma, bronchospasm, chronic obstructive pulmonary disease (COPD), and pulmonary disease with spastic bronchial component. It is a novel bronchodilator that selectively inhibits phosphodiesterase 4 to relax bronchial smooth muscle. Doxiflo should be used as per the prescribed dosage by a physician and is contraindicated in individuals with known hypersensitivity to the drug or other xanthine derivatives. It may have side effects such as nausea, vomiting, headache, tachycardia, and requires careful evaluation during pregnancy and lactation. It should be stored in a dry place away from light and heat, and kept out of the reach of children.
Dosage & Administration
- Elderly: 200mg tablet two or three times daily
- Adults: 400mg tablet two or three times daily
- Children (>12 years): 10ml syrup or 200mg tablet two or three times daily
- Children (6-12 years): 6-9mg/kg body weight two times daily
- If required daily dose of Doxiflo is 400mg then Doxiflo SR tablet to be taken once daily
Pharmacology
Doxiflo selectively inhibits phosphodiesterase 4 to relax bronchial smooth muscle and differs from Theophylline in its safety profile and affinity towards adenosine receptors.
Interaction
Doxiflo should not be administered with other xanthine preparations and caution should be exercised in administering it with ephedrine or other sympathomimetic drugs. Concurrent administration of drugs such as erythromycin, TAO, lincomycin, and others may affect hepatic clearance.
Contraindications
Doxiflo is contraindicated in individuals with known hypersensitivity to the drug or other xanthine derivatives, as well as in patients with acute myocardial infarction, hypotension and during lactation.
Side Effects
- Nausea
- Vomiting
- Headache
- Tachycardia
- Hyperglycemia
- Albuminuria
Pregnancy & Lactation
The effects of Doxiflo during pregnancy have not been sufficiently studied, and its use should be carefully evaluated case by case on the basis of the risk-benefit ratio. It is contraindicated during lactation.
Precautions & Warnings
Caution should be taken in administering Doxiflo to patients with cardiac disease, hypertension, in the elderly, in patients with severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcer, and in those with renal impairment. Monitoring of blood levels is recommended for patients with factors that may influence drug clearance.
Overdose Effects
In case of overdose, severe cardiac arrhythmias and tonic-clonic seizure may occur, requiring discontinuation of the treatment and a symptomatic treatment of cardiovascular collapse.
Therapeutic Class
Bronchodilator, Methyl Xanthine Derivative
Storage Conditions
Keep in a dry place away from light and heat, and out of the reach of children.