Olmesafe-HT 20 mg+12.5 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olmesartan medoxomil hydrochlorothiazide |
| Company | Orion pharma ltd |
Indications
- Treatment of hypertension
Pharmacology
- Olmesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin-II
- Hydrochlorothiazide affects the renal tubular mechanisms of electrolyte reabsorption
Dosage & Administration
- Usual starting dose is 20/12.5 mg once daily
- May be titrated to two tablets 40/25 mg once daily
Interaction
- Olmesartan has no significant drug interactions reported
- Hydrochlorothiazide may interact with alcohol, barbiturates, narcotics, antidiabetic drugs, other antihypertensive drugs, corticosteroids, ACTH, and lithium
Contraindications
- Hypersensitivity to any component of the product
- Anuria or hypersensitivity to sulfonamide-derived drugs
Side Effects
- Nausea
- Headache
- Dizziness
- Hyperuricemia
- Upper respiratory tract infection
- Urinary tract infection
- Chest pain
- Back pain
- Peripheral edema
- Abdominal pain
- Dyspepsia
- Gastroenteritis
- Diarrhea
Pregnancy & Lactation
- Safety and effectiveness not established
- Discontinuation during pregnancy and lactation recommended
Precautions & Warnings
- Periodic determination of serum electrolytes
- Hyperuricemia risk
- Impaired renal function
Use in Special Populations
- Renal impairment patients - therapy regimen based on creatinine clearance
- Hepatic impairment patients - no dosage adjustment necessary
- Paediatric use - safety and effectiveness not established
- Geriatric use - cautious dose selection recommended
Overdose Effects
- Olmesartan - likely hypotension and tachycardia
- Hydrochlorothiazide - signs and symptoms of electrolyte depletion and dehydration
Therapeutic Class
- Combined antihypertensive preparations
Storage Conditions
- Store in cool and dry place
- Protect from light and moisture
- Keep out of reach of children