Vertex 250 mg/vial (IM Injection)

250 mg vial: ৳ 100.30

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Orion pharma ltd
Also available as
Vertex 250 mg injection Vertex 500 mg injection Vertex 1 gm injection Vertex 2 gm injection Vertex 1 gm injection Vertex 500 mg injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

  • Broad-spectrum parenteral cephalosporin antibiotic
  • Bactericidal activity against a wide range of Gram-positive and Gram-negative organisms
  • Interferes with the synthesis of the bacterial cell wall
  • High degree of stability in the presence of beta lactamases
  • Relatively long plasma elimination half-life of about 6 to 9 hours
  • Not metabolized in the body
  • About 40-65% of a dose excreted unchanged in the urine
  • Highly protein bound (95%)

Dosage

  • Usual adult dose is 1 to 2 gm by intravenous or intramuscular administration once a day
  • Maximum dose for adults: 4 gm/day
  • Usual dose for infants and children is 50 to 75 mg/kg intravenous or intramuscular administration once a day
  • Maximum dose for infants and children: 2 gm/day
  • Duration of therapy: 4 to 14 days

Administration

  • Preparation of solutions for intramuscular / intravenous injections
  • Injection should be administered over 2-4 minutes
  • Patient tolerance test should be checked by administration of a test dose
  • Maintains potency for at least 6 hours at room temperature or 24 hours at 5°C

Interaction

  • No drug interactions have been reported

Contraindications

  • Do not give to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting, stomatitis and glossitis
  • Cutaneous reactions including rash, pruritus, urticaria, edema and erythema multiforme
  • Hematologic reactions including eosinophilia, thrombocytopenia, leucopenia, anemia and neutropenia
  • Hepatic reactions including elevations of SGOT or SGPT, bilirubinemia
  • CNS reactions including nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsion, hypertonia and dizziness
  • Local phlebitis occurs rarely

Pregnancy & Lactation

  • Not established for human pregnancy, caution in lactating mothers

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder in rare cases
  • Blood picture should be checked at regular intervals during prolonged treatment

Use in Special Populations

  • Must not be given to premature and newborn neonates

Overdose Effects

  • No specific antidote, treatment should be symptomatic

Therapeutic Class

  • Third generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place below 30°C, away from light and moisture

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