Rexiet 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (5 x 10: ৳ 400.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Labaid pharma ltd
Also available as
Rexiet 10 mg capsule

Title

  • Rexiet Gastro-resistant Tablets

Therapeutic Class

  • Proton Pump Inhibitor

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • GERD
  • Gastro-esophageal Reflux Disease Long-term Management
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • 20 mg once daily in the morning for active duodenal ulcer and active benign gastric ulcer
  • 20 mg once daily for four to eight weeks for erosive or ulcerative GERD
  • 10 mg once daily for symptomatic treatment of moderate to very severe GERD
  • 60 mg once a day for Zollinger-Ellison Syndrome, may be titrated upwards to 120 mg/day
  • 20 mg twice daily for 7 days in eradication of H. pylori

Administration

  • Oral intake in the morning before eating
  • Swallowed whole without chewing or crushing

Interaction

  • May interact with compounds with pH-dependent absorption
  • May decrease antifungal plasma levels when co-administered with ketoconazole or itraconazole
  • No interaction with liquid antacids observed
  • Not recommended to be co-administered with atazanavir

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Increased or decreased appetite
  • Muscle pain
  • Drowsiness
  • Dizziness

Pregnancy Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely to be excreted in human milk

Precautions Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric or oesophageal malignancy
  • Regular surveillance for long-term treatment
  • Potential to increase the risk of hip, wrist and spine fracture, particularly in the elderly
  • Risk of cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles
  • Careful monitoring for blood dyscrasias and hepatic enzyme abnormalities
  • Caution in patients with severe hepatic dysfunction
  • May possibly increase the risk of gastrointestinal infections
  • Risk of hypomagnesaemia and reduced vitamin B12 absorption
  • Association with subacute cutaneous lupus erythematosus (SCLE)
  • Interference with laboratory tests like increased Chromogranin A (CgA) level

Use in Special Populations

  • No dosage adjustment necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of safety and efficacy data

Overdose Effects

  • Maximum established exposure not exceeding 60 mg twice daily or 160 mg once daily
  • Effects generally minimal, reversible without further medical intervention
  • No specific antidote known
  • Extensively protein bound and not dialysable

Storage Conditions

  • Below 30°C temperature, away from light and moisture
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H21N3O3S
  • Chemical Structure Image URL: https://medex.com.bd/storage/res/g-res-942-rabeprazole-sodium-chemical-structure-atwg0Q4PlndQZhOY9GHX.svg

Common Questions

  • What is Rexiet 20 mg Capsule: A PPI that suppresses gastric acid secretion
  • What is it used for: Treatment in Duodenal ulcer, Gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
  • Side Effects: Diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, dry mouth, rare serious side effects like kidney problems, liver damage, and bone fractures
  • How to take: With food, usual dose is one tablet once a day, do not exceed prescribed dose
  • Pregnancy Lactation: Not recommended for use during pregnancy or breastfeeding, discuss risks and benefits with the doctor
  • Overdose: Call doctor or Poison Control Center immediately, may cause symptoms like drowsiness, confusion, and seizures
  • Duration of Treatment: Varies based on the condition being treated, typically 4-8 weeks for GERD
  • Other Information:
    • Can cause dry mouth and constipation, long term use can cause osteoporosis, can be taken with vitamin D, quick tips for usage and precautions

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