Angilock 25 mg (Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily if 50 mg is inadequate
- 25 mg once daily for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- Different starting doses for patients aged 75 and over
- Can be administered once or twice daily
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Potential increases in serum potassium with potassium-sparing diuretics or supplements
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with concurrent use of certain medications
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component of the product
- Not to be administered with Aliskiren in diabetic patients
Side Effects
- Mild and transient side effects
- Common side effects including dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects such as fatigue, edema, abdominal pain, chest pain, and headache
Pregnancy & Lactation
- Pregnancy Category D
- Increased fetal risk in second or third trimesters
- Potential excretion in human milk
- Adverse effects on nursing infants
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death in second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function and renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment for mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose for patients with a history of hepatic impairment
- Administration with other antihypertensive agents
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children