Angilock 50 mg (Tablet)
Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of hypertension
- Delaying progression of renal disease in hypertensive type-2 diabetics with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50mg once daily
- 25mg twice daily for inadequate antihypertensive effect
- Range of total daily doses from 25mg to 100mg
- Lower starting dose of 25mg for patients over 75 years
Interaction
- Reduced levels with rifampicin and fluconazole
- Potentiation with hydrochlorothiazide
- Increase in serum potassium with potassium-sparing diuretics
- Attenuation by indomethacin
- Increased risk of renal impairment with ACE-inhibitor, angiotensin receptor antagonist, and thiazide diuretic
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component of the product
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus increases if administered during second or third trimesters
- Decision regarding nursing in consideration of potential adverse effects on the nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased fetal and neonatal morbidity and death in second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function and renal failure reported in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
- Lower dose recommended for patients with hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children