Exilok 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.00 (5 x 10: ৳ 350.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Osl pharma limited
Also available as
Exilok 20 mg capsule Exilok 40 mg capsule Exilok 40 mg tablet Exilok 40 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease in combination with amoxicillin and clarithromycin
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Absorption
  • Distribution
  • Metabolism by cytochrome P450 (CYP) enzyme system
  • Excretion
  • Combination Therapy with Antimicrobials

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori eradication: Triple Therapy with Esomeprazole 40 mg Once Daily for 10 days, Amoxicillin 1000 mg Twice Daily for 10 days, Clarithromycin 500 mg Twice Daily for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg Once Daily
  • Acid-related Dyspepsia: 20-40 mg Once Daily for 2-4 weeks
  • Duodenal ulcer: 20 mg Once Daily for 2-4 weeks
  • IV Injection or IV infusion for various conditions

Administration

  • Oral dosage form instructions
  • Oral Suspension instructions
  • IV Injection instructions

Interaction

  • Metabolism by CYP2C19 and CYP3A4
  • Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • Potential interference with CYP2C19
  • Clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
  • Impact on absorption of drugs affected by gastric pH

Contraindications

  • Known hypersensitivity to the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breast-feeding discontinuation recommended if essential use during lactation

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Instructions for patients
  • Use with antacids
  • Swallowing alternatives for patients with difficulty swallowing capsules

Use in Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed between age groups
  • Hepatic and Renal Insufficiency considerations

Overdose Effects

  • Signs of acute toxicity in animal studies
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Temperature not exceeding 30°C
  • Protection from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common Questions about Exilok 20 mg Tablet

  • Question1: What is Exilok 20 mg Tablet?
  • Answer1: Proton pump inhibitor used for treating gastroesophageal reflux disease (GERD), ulcers, and conditions involving excess stomach acid production
  • Question2: What is Exilok 20 mg Tablet used for?
  • Answer2: Relief from heartburn, healing erosive esophagitis, preventing its recurrence
  • Question3: What are the side effects of Exilok 20 mg Tablet?
  • Answer3: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
  • Question4: Can I take Exilok 20 mg Tablet if I am pregnant or breastfeeding?
  • Answer4: Consider risks and benefits, discontinue breast-feeding if essential
  • Question5: How long does it take for Exilok 20 mg Tablet to work?
  • Answer5: Usually starts working within a few hours

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