Exilok 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 8.03 (5 x 10: ৳ 401.50)
Strip Price: ৳ 80.30

Medicine Details

Category Details
Generic Esomeprazole
Company Osl pharma limited
Also available as
Exilok 20 mg capsule Exilok 40 mg capsule Exilok 20 mg tablet Exilok 40 mg injection

Title

Exilok 40 mg Tablet

Categories

  • Medication
  • Pharmaceutical

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid related Dyspepsia
  • Treatment of duodenal and gastric ulcers

Mode of Action

  • Proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase
  • Provides better acid control than racemic proton pump inhibitors
  • Absorption after oral administration: Peak plasma levels occur at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver by cytochrome P450 (CYP) enzyme system
  • Excretion: Plasma elimination half-life is approximately 1–1.5 hours

Dosage

  • Oral Dosage Form:
    • Healing of Erosive Esophagitis: 20 mg or 40 mg once daily for 4-8 weeks
    • Symptomatic GERD: 20 mg once daily for 4 weeks
    • Helicobacter Pylori eradication: 40 mg once daily for 10 days
    • Zollinger-Ellison Syndrome: 20-80 mg once daily
    • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks

Administration

  • Tablet or capsule: Should be swallowed whole and taken one hour before a meal
  • Oral Suspension: Should be taken into a small glass containing 15 ml of water and stirred well
  • IV Injection: Must be administered over a period of at least 3 minutes

Interaction

  • Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Relevance to Other Drugs: Not likely to inhibit certain CYP enzymes or have clinically relevant interactions with specific drugs
  • Potential Effects on Other Drugs: May interfere with the absorption of drugs sensitive to gastric pH, and increase plasma levels of certain drugs

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Most Frequently Occurring Adverse Events:
    • Headache
    • Diarrhoea
    • Nausea
    • Flatulence
    • Abdominal pain
    • Constipation
    • Dry mouth

Pregnancy & Lactation

  • Pregnancy: No adequate and well-controlled studies; animal studies revealed no teratogenic effects
  • Lactation: Excretion of esomeprazole in milk has not been studied; breastfeeding should be discontinued if use is considered essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals

Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed between the elderly and younger individuals
  • Hepatic Insufficiency: No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Renal Insufficiency: Pharmacokinetics not expected to be altered relative to healthy volunteers

Overdose Effects

  • Lethal Dose in Rats: Single oral dose at 510 mg/kg
  • Major Signs of Acute Toxicity:
    • Reduced motor activity
    • Changes in respiratory frequency
    • Tremor
    • Ataxia
    • Intermittent clonic convulsions
  • Management: Treatment should be symptomatic and supportive; no specific antidote known

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place; protect from light and moisture; keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Commonly Asked Questions

  • Exilok 40 mg Tablet:
    • What it is: A proton pump inhibitor used to reduce the amount of acid produced in the stomach
    • Uses: Treatment of gastroesophageal reflux disease (GERD), ulcers, and other conditions related to excess stomach acid
    • Side Effects: May cause headaches, diarrhea, nausea, and other common adverse events
    • Pregnancy & Breastfeeding: No significant side-effects known, but consult a doctor for risks and benefits
    • Time to Work: Usually starts to work within a few hours of taking it
    • Quick Tips:
      • List:
        • Well-tolerated and provides long-term relief
        • Avoid eating late at night or before bedtime
        • Consult a doctor for persistent symptoms or special precautions

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