Rotalac 60 mg/2 ml (IM/IV Injection)
2 ml ampoule: ৳ 95.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Pharmasia limited |
| Also available as |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decreasing eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
- Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Biological activity associated with the S-form
- Linear pharmacokinetic property, highly protein bound and largely metabolized in the liver
- Metabolites and some unchanged drugs excreted in the urine
Pharmacology
- Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
- Acts by inhibiting the cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at its analgesic dose
Dosage & Administration
- Tablet dosage: 10 mg every 4-6 hours, short-term use only (up to 7 days)
- Injection dosage: Single or multiple doses for the management of moderately severe, acute pain
- Eye Drops dosage: 1 drop in each eye, 4 times daily
Interaction
- Other NSAIDs or aspirin: Increase the side effects of Rotalac
- Anti-coagulants: Enhance anti-coagulant effect
- Beta Blocker: Reduce the anti-hypertensive effect
- ACE Inhibitors: Increase the risk of renal impairment
- Methotrexate: Enhance the toxicity of methotrexate
Contraindications
- Hypersensitivity to the drug or other NSAIDs
- Not recommended for use in children under 16 years of age
- Contraindicated as a prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category of Ketorolac Tromethamine is C
- Should be avoided in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over the age of 65 years
- Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
- Discontinue use of topical NSAIDs and monitor corneal health in patients with evidence of corneal epithelial breakdown
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children