Xelpro 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole |
| Company | Pharmasia limited |
| Also available as |
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection
- Treatment for Zollinger-Ellison Syndrome
- Treatment for Acid related Dyspepsia
- Treatment for Duodenal ulcer
- Treatment for Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppression of gastric acid secretion
- Specific inhibition of the H+/K+-ATPase
- First single optical isomer of proton pump inhibitor
- Peak plasma levels occur at approximately 1.5 hours after oral administration
- 90% systemic bioavailability after repeated once daily dosing
- Extensively metabolized in the liver by cytochrome P450 (CYP) enzyme system
- Plasma elimination half-life is approximately 1–1.5 hours
Dosage
- Oral dosage form
- Healing of Erosive Esophagitis
- Symptomatic GERD
- Helicobacter Pylori eradication
- Zollinger-Ellison Syndrome
- Acid-related Dyspepsia
- Duodenal ulcer treatment
- Initial IV Injection
- Maintenance of healing
- Dosage varies for pediatric patients and body weights
- Risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy
Administration
- Swallowed whole and taken one hour before a meal (tablet or capsule)
- Instructions for Oral Suspension administration
- Preparation of IV Injection solution
- IV Injection must be administrated intravenously over a period of at least 3 minutes
Interaction
- Metabolized in the liver by CYP2C19 and CYP3A4
- Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
- Potentially interferes with CYP2C19
- Possible interference with the absorption of certain drugs
- No clinically significant interactions with specific drugs
Contraindications
- Contraindicated in patients with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhoea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Animal studies have revealed no teratogenic effects
- Excretion in milk has not been studied
- Breastfeeding should be discontinued if essential
Precautions & Warnings
- Symptomatic response to therapy does not preclude the presence of gastric malignancy
- Instructions for patients
- Information about taking antacids while using the product
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- No overall differences in safety and efficacy observed between the elderly and younger individuals
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
Overdose Effects
- Major signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions
- No specific antidote known
- Treatment should be symptomatic and supportive
Storage Conditions
- Store at a temperature not exceeding 30°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
Common Questions about Xelpro 40 mg Capsule
- Description of Xelpro 40 mg Capsule
- Uses of the product
- Common side effects
- Use during pregnancy or breastfeeding
- Duration for product to take effect
- Quick tips for using Xelpro 40 mg Capsule