Esobest 40 mg (Tablet (Enteric Coated))
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Relief from chronic heartburn symptoms and other symptoms associated with GERD
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Zollinger-Ellison Syndrome
- Acid related Dyspepsia
- Duodenal & Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppresses gastric acid secretion
- Inhibits the H+/K+-ATPase
- Better acid control than racemic proton pump inhibitors
- Enteric-coated pellet formulation
- Absorption peak at approximately 1.5 hours
- Plasma protein binding of 97%
- Extensively metabolized in the liver
- Plasma elimination half-life of approximately 1–1.5 hours
Dosage
- 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
- 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
- 20 mg Once Daily for Symptomatic GERD for 4 Weeks
- Triple Therapy for Helicobacter Pylori eradication
- 20-80 mg once daily for Zollinger-Ellison Syndrome
- 20-40 mg once daily for Acid-related Dyspepsia
- 20 mg once daily for 2-4 weeks for Duodenal ulcer
- 20-40 mg once daily for 4-8 weeks for Gastric ulcer
- Dosage for IV injection and infusion
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral Suspension instructions
- IV Injection solution preparation and administration
Interaction
- Extensively metabolized by CYP2C19 and CYP3A4
- No clinically relevant interactions with certain CYP enzymes
- Potential interference with CYP2C19
- Inhibition of gastric acid secretion
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- No studies on excretion of esomeprazole in milk
- Breast-feeding discontinuation if esomeprazole use is essential
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Administration instructions
- Use of antacids while taking esomeprazole
Use in Special Populations
- Safety and effectiveness in paediatric patients not established
- No overall differences in safety and efficacy in geriatric use
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Expected unaltered Pharmacokinetics in patients with renal impairment
Overdose Effects
- Lethal dose in rats
- Major signs of acute toxicity
- No specific antidote known
- Symptomatic and supportive treatment recommended
Storage Conditions
- Temperature not exceeding 30°C
- Dry place
- Protection from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure visualization
Common Questions about Esobest 40 mg Tablet
- Description
- Uses
- Side effects
- Pregnancy and breastfeeding considerations
- Time for effectiveness
- Quick Tips