Esomups 40 mg (MUPS Tablet)

Title

• EsoMUPS Tablet

Categories

• Medicine
• Gastrointestinal Health
• Acid Reducer

Indications

• Gastro-esophageal Reflux Disease (GERD)
• Risk reduction in NSAID associated gastric ulcer
• H. pylori eradication (Triple therapy)
• Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

• Esomeprazole MUPS 20 Tablet
• Esomeprazole MUPS 40 Tablet

Dosage

• Erosive esophagitis
• Maintenance of healing of erosive esophagitis
• H. pylori eradication
• Zollinger-Ellison syndrome and idiopathic hypersecretion

Mode of Action

• Inhibits gastric acid production by blocking the proton pump enzyme system in the gastric parietal cell

Administration

• Swallow whole with liquid
• Can be dispersed in water if necessary

Interaction

• Metabolized in the liver by CYP2C19 and CYP3A4
• Potential interactions with diazepam, ketoconazole, iron salts, digoxin, and clarithromycin

Contraindications

• Known hypersensitivity to any of the formulation

Side Effects

• Headache
• Diarrhea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth

Pregnancy & Lactation

• Caution advised, unknown if excreted in human breast milk

Precautions & Warnings

• Use with caution in severe liver dysfunction and severe renal impairment
• May slightly increase the risk of hip, wrist, and spine fracture with long-term use

Storage Conditions

• Store below 25°C, protect from light, keep out of reach of children

Chemical Structure

• Molecular Formula: C17H19N3O3S
• Chemical Structure Image: [URL]

Commonly Asked Questions

• Uses of Esomups 40 mg MUPS Tablet
• Side effects of Esomups 40 mg MUPS Tablet
• Pregnancy and breastfeeding related queries

Usability Features

• Rapid dissolution in the gastrointestinal tract
• Uniform drug absorption
• Once daily dosing for convenience
• Reduction in inter- and intra-subject variability in drug absorption

Technical Specifications

• Esomeprazole enteric coated pellets
• 20 mg and 40 mg tablet strengths

Design Elements

• Modified release coated multiparticulates or pellets in tablet form
• Greater bioavailability compared to traditional formulations

Materials

• Esomeprazole Magnesium Trihydrate USP
• Enteric coated pellets

Functions

• Reduction of gastric acid production
• Treatment of GERD and ulcers

Color Options

• Typically white or off-white tablets

Dimensions

• Standard tablet dimensions

Absorption

• Facilitates controlled and consistent pharmacological action

Bioavailability

• Ensures better and more uniform drug absorption
• Lowers fluctuation in plasma concentration of drug

Inhibition

• Inhibits gastric acid by blocking the proton pump enzyme system

Absorption Process

• Uniform drug absorption due to small size and larger surface of pellets

Pharmacokinetic Profile

• Does not significantly alter the pharmacokinetic profiles of certain drugs

Dose Administration

• Specific dosing requirements for different age groups

Drug Release

• Uniform drug release due to multiple-unit pellet system

Capsule Comparison

• Improved properties compared to traditional capsule formulations

Local Irritation

• Minimal chance of localized irritation

Clinical Response

• Reduction in inter- and intra-subject variability in drug absorption and clinical response

Drug Dissolution

• Facilitated by rapid and uniform gastric emptying

Emptying Process

• Uniform emptying of micro pellets from stomach into small intestine

Dose Dumping

• Lesser possibility of dose dumping

Child Use

• Limited approval for use in children below certain ages

Gastric pH Interference

• Potential interference with absorption of drugs affected by gastric pH

Metabolizing Enzymes

• Extensively metabolized in the liver by CYP2C19 and CYP3A4

Plasma Levels

• Influence on plasma levels of certain drugs

Gastrict Acid Inhibition

• Proton pump inhibitor effect on gastric acid secretion

Adverse Events

• Frequent adverse events include headache, diarrhea, nausea, and abdominal pain

Long-Term Use

• Considerations for long-term use and associated risks

Bone Health

• Potential increased risk of fractures with prolonged use

Mineral Deficiency

• Possible deficiency of minerals such as magnesium with long-term use

Risks and Benefits

• Need for discussion of risks and benefits during pregnancy and breastfeeding

Onset of Action

• Work starts within a few hours of administration

User Tips

• Guidelines for use and potential side effects

Consultation

• Advisability of consulting a doctor for specific scenarios

Medical Guidance

• Importance of medical supervision for certain conditions

Adequate Storage

• Instructions for proper storage to maintain product integrity

Safety Precautions

• Caution in cases of severe liver dysfunction and renal impairment

Fracture Risk

• Increased risk of hip, wrist, and spine fracture with prolonged use

Dispersal Method

• Instructions for dispersing the tablet in water if necessary

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