Anreb 25 mg (Tablet)
Unit Price: ৳ 4.51 (5 x 10: ৳ 225.45)
Strip Price: ৳ 45.09
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting dose of 50 mg once daily
- Maintenance dose ranges from 25 mg to 100 mg daily
- Different dosage recommendation for patients over 75 years
Interaction
- Reduction in active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Possible increase in serum potassium with potassium-sparing diuretics or supplements
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component of the product
- Not to be used with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, and nasal congestion
- Additional side effects such as fatigue, edema, and abdominal pain
Pregnancy & Lactation
- Pregnancy Category D
- Increase in fetal risk when administered during second or third trimester
- Potential excretion in human milk and impact on nursing infant
Precautions & Warnings
- Reduced fetal renal function and increased morbidity if used in second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
Use in Special Populations
- No initial dosage adjustment for patients with mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Consideration of lower dose for patients with hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children