Levat 10 mg (Capsule)
Unit Price: ৳ 1,730.00 (1 x 30: ৳ 51,900.00)
Strip Price: ৳ 51,900.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lenvatinib mesylate |
| Company | Jenphar bangladesh ltd |
| Also available as |
Indications
- Differentiated Thyroid Cancer
- Renal Cell Carcinoma
- Hepatocellular Carcinoma
- Endometrial Carcinoma
Pharmacology
- Kinase inhibitor
- Inhibits VEGF receptors
- Inhibits FGF receptors
- Inhibits platelet-derived growth factor receptor alpha
- Antiproliferative activity in hepatocellular carcinoma cell lines
Dosage
- Dose reduction for renal or hepatic impairment
- Recommended dosages for indicated cancers
Administration
- Can be swallowed whole or dissolved in liquid
Interaction
- Prolongs QT interval
- Avoid coadministration with drugs that prolong QT interval
Contraindications
- Known hypersensitivity to Lenvatinib
Side Effects
- Hypertension
- Cardiac dysfunction
- Arterial thromboembolic events
- Hepatotoxicity
- Renal failure and impairment
- Proteinuria
- Diarrhea
- Fistula formation and gastrointestinal perforation
- QT Interval Prolongation
- Hypocalcemia
- Reversible Posterior Leukoencephalopathy Syndrome
- Hemorrhagic events
- Impairment of thyroid stimulating hormone suppression/thyroid dysfunction
- Wound healing complications
Pregnancy & Lactation
- Causes embryo-fetal harm
- Advisory for pregnant and lactating women
Precautions & Warnings
- Hypertension monitoring and control
- Monitoring for cardiac dysfunction
- Arterial thromboembolic event precautions
- Hepatotoxicity monitoring
- Renal Failure or Impairment precautions
- Proteinuria monitoring
- Diarrhea management
- Fistula Formation and Gastrointestinal Perforation precautions
- QT Interval Prolongation monitoring
- Hypocalcemia management
- Reversible Posterior Leukoencephalopathy Syndrome precautions
- Hemorrhagic Events risk assessment
- Impairment of Thyroid Stimulating Hormone Suppression/Thyroid Dysfunction monitoring
- Wound Healing Complications precautions
Use in Special Populations
- Dosage Modifications for Severe Renal Impairment
- Dosage Modifications for Severe Hepatic Impairment
- Safety and effectiveness in pediatric patients not established
Overdose Effects
- Not expected to be dialyzable
- Death in a patient who received a single dose of 120 mg orally
Storage Conditions
- Store below 30°C
- Dry place
- Protect from light
- Keep out of the reach of children