Razithro 500 mg (Tablet)

Title

• Razithro 500 mg Tablet

Categories

• Antibiotic
• Medication
• Infection Treatment

Description

• Razithro is indicated for a range of infections in the respiratory tract, skin, and sexually transmitted diseases.
• Azithromycin is absorbed easily and its high concentration in phagocytes allows it to be transported to the site of infection.
• Razithro is available as an oral tablet and injection for IV infusion.
• Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms, interfering with protein synthesis.

DosageOptions

• 500 mg once daily orally for 3 days for adult
• 10 mg/kg body weight once daily for 3 days for children over 6 months
• 500 mg as a single daily dose for at least two days for community-acquired pneumonia in adults
• Add boiled and cooled water up to the water mark of the bottle label for reconstitution of suspension

AdministrationInstructions

• Shake the bottle well to loosen the powder before reconstitution
• Azithromycin should be taken at least 1 hour before or 2 hours after a meal

InteractionEffects

• Azithromycin and antacids should be taken at least 1 hour apart
• Closely monitor cyclosporin levels if co-administered with azithromycin
• The possibility of raised digoxin levels should be monitored when received concomitant azithromycin and digoxin

Contraindications

• Hypersensitivity to Azithromycin or any other macrolide antibiotic
• Co-administration of ergot derivatives and Azithromycin
• Patients with hepatic diseases

SideEffects

• Mild to moderate gastrointestinal side-effects such as nausea, abdominal discomfort, vomiting, and diarrhea
• Allergic reactions like rash or photosensitivity reported
• Rare cases of serious hypersensitivity reactions and cholestatic jaundice observed
• Reversible elevations in liver transaminases seen

PregnancyAndLactation

• Pregnancy Category B with no evidence of harm to the fetus in animal reproduction studies
• Caution exercised when administered to nursing women

PrecautionsAndWarnings

• Rare serious allergic reactions reported
• Use caution in patients with renal impairment and avoid in patients with severe hepatic disease

OverdoseEffects

• Symptoms may include hearing loss, severe nausea, vomiting, and diarrhea
• Gastric lavage and general supportive measures recommended

StorageConditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

ChemicalStructure

• Molecular Formula: C38H72N2O12

CommonQuestions

• Razithro 500 mg Tablet is an antibiotic used for the treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections
• Side effects include diarrhea, dry or scaly skin, abdominal pain, and more
• Razithro 500 mg Tablet should be kept in a cool dry place and its original packaging
• It may cause diarrhea, and it is safe if used at prescribed doses

RenalImpairmentUse

• No dose adjustment needed in patients with mild renal impairment
• Caution exercised in using azithromycin in patients with more severe renal impairment

HepaticImpairmentUse

• Not to be used in patients with hepatic disease

AbilityToDriveAndUseMachines

• No evidence to suggest that azithromycin may have an effect on a patient's ability to drive or operate machinery

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