Doxocontin 400 mg (Tablet (Controlled Release))
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Mundipharma bd pvt ltd |
| Also available as |
Title
- Doxocontin
Categories
- Bronchodilator
- Methyl xanthine derivatives
Description
- Novel bronchodilator
- Selective phosphodiesterase 4 inhibitor
- Relaxes bronchial smooth muscle
- Decreased affinities toward adenosine A1 and A2 receptors
- Inhibits platelet activating factor (PAF) and leukotriene production
Indications
- Bronchial asthma
- Bronchospasm
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary disease with spastic bronchial component
Pharmacology
- Structurally differs from Theophylline
- Contains dioxolane group in position 7
- Reported to inhibit platelet activating factor (PAF)
- Decreased affinities toward adenosine A1 and A2 receptors
Dosage & Administration
- Elderly: 200 mg tablet two or three times daily
- Adults: 400 mg tablet two or three times daily
- Children:
- >12 years of age: 10 ml syrup or 200 mg tablet two or three times daily
- 6-12 years of age: 6-9 mg/kg body weight two times daily
- Special Cases: Doxophylline SR tablet to be taken once daily if required daily dose is 400 mg
Interaction
- Not to be administered with other xanthine preparations
- Limit consumption of beverages and food containing caffeine
- Caution with ephedrine or other sympathomimetic drugs
- Concurrent administration of erythromycin, TAO, lincomycin, etc.
- Phenytoin, other anticonvulsants, and cigarette smoking may increase clearance
Contraindications
- Known hypersensitivity to the drug or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- During lactation
Side Effects
- Nausea
- Vomiting
- Headache
- Insomnia
- Tachycardia
- Tachypnea
- Hyperglycemia
- Albuminuria
- Severe cardiac arrhythmias in case of overdose
Pregnancy & Lactation
- Not sufficient clinical evidence during pregnancy
- Use during pregnancy should be evaluated on risk-benefit ratio
- Contraindicated during lactation
Precautions & Warnings
- Factors may reduce hepatic clearance of xanthine derivatives
- Monitoring of blood levels recommended in certain cases
- Caution in patients with cardiac disease, hypertension, hypoxemia, etc.
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- Symptomatic treatment of cardiovascular collapse in case of overdose
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children. Should be used only on prescription of specialist physician.