Araten 50 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Unimed unihealth pharmaceuticals ltd |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- Lower starting dose of 25 mg once daily for patients over 75 years
- Total daily dose ranges from 25 mg to 100 mg
Interaction
- Rifampicin and fluconazole reduce active metabolite levels
- Concomitant use with hydrochlorothiazide may potentiate effects
- Concomitant use with potassium-sparing diuretics or supplements may result in increased serum potassium
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component of the product
- Avoid administration with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, and cough
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to the fetus in second or third trimesters
- Excretion in human milk not known, potential for adverse effects on nursing infant
Precautions & Warnings
- Reduces fetal renal function in second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function, including renal failure, reported in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment (creatinine clearance 20-50 ml/min)
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Use with caution in patients with hepatic impairment
- Contraindicated in pregnancy and in patients hypersensitive to losartan
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children