Diclofen 100 mg (Suppository)

Unit Price: ৳ 20.00 (2 x 5: ৳ 200.00)

Medicine Details

Category	Details
Generic	Diclofenac sodium
Company	Opsonin pharma ltd
Also available as	Diclofen 25 mg tablet Diclofen 50 mg tablet Diclofen sr 100 mg tablet Diclofen 1 w gel Diclofen 75 mg injection Diclofen 125 mg suppository Diclofen 25 mg suppository Diclofen 50 mg suppository Volifen 1 v spray

Indications

Inflammatory and degenerative forms of rheumatism
Chronic involutive polyarthritis
Ankylosing spondylarthritis
Osteoarthritis
Acute gout
Sprains
Bruises
Dislocations
Fractures
Soft tissue injuries
Episiotomy
Adnexitis
Endometritis
Parametritis
Salpingitis
Mastitis
Pre-operative medication for the prevention of pain, inflammation, and swelling
Post-operative and post-traumatic pain, inflammation, and swelling
Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
Renal and biliary colic

Pharmacology

Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic, and antipyretic properties. It has some uricosuric effect. Inhibits prostaglandin biosynthesis which plays a major role in causing inflammation, pain, and fever. Rapid and complete absorption from the gastro-intestinal tract. Metabolized in the liver and undergoes first-pass metabolism.

Dosage & Administration

Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food
Children: 1-3 mg of diclofenac/kg body weight daily in divided doses
Elderly patients: Lowest effective dosage recommended
Maximum daily dose for suppository is 150 mg
1 ampoule of injection daily for adults
2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily for external use

Interactions

Increased plasma concentrations of lithium and digoxin
Isolated reports of an increased risk of haemorrhage with the combined use of diclofenac and anticoagulant therapy
Can be given together with oral antidiabetic agents without influencing their clinical effect
Caution should be exercised when considering concomitant therapy of NSAID and quinolones
Co-administration with other systemic NSAIDs and steroids may increase the frequency of unwanted effects
Plasma levels of each is lowered with aspirin, although no clinical significance is known

Contraindications

Hypersensitivity to any ingredient of the products
Peptic ulcer
Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
Contra-indicated in asthmatic patients in whom attack with asthma, urticaria, or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
Gel should not be used under occlusive airtight dressings

Side Effects

Mild, rare, and transient adverse effects
Epigastric pain
Eructation
Nausea
Diarrhea
Dizziness
Headache
Peripheral edema
Skin reactions such as rash and eczema
Local irritation and reddening of the skin
Skin rash

Pregnancy & Lactation

Employed only for compelling reasons during pregnancy
Lowest effective dose should be used
Not recommended during the first trimester of pregnancy
Not recommended during lactation due to insufficient clinical data

Precautions & Warnings

Close observation in patients with rare peptic ulceration or gastrointestinal bleeding
Should not come in contact with eyes or mucus membranes
Hands should be washed properly after application
Not to be taken by mouth

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children