Diclofen 100 mg (Suppository)
Unit Price: ৳ 20.00 (2 x 5: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diclofenac sodium |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Inflammatory and degenerative forms of rheumatism
- Chronic involutive polyarthritis
- Ankylosing spondylarthritis
- Osteoarthritis
- Acute gout
- Sprains
- Bruises
- Dislocations
- Fractures
- Soft tissue injuries
- Episiotomy
- Adnexitis
- Endometritis
- Parametritis
- Salpingitis
- Mastitis
- Pre-operative medication for the prevention of pain, inflammation, and swelling
- Post-operative and post-traumatic pain, inflammation, and swelling
- Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
- Renal and biliary colic
Pharmacology
Potent non-steroidal anti-inflammatory drug (NSAID) with pronounced anti-rheumatic, anti-inflammatory, analgesic, and antipyretic properties. It has some uricosuric effect. Inhibits prostaglandin biosynthesis which plays a major role in causing inflammation, pain, and fever. Rapid and complete absorption from the gastro-intestinal tract. Metabolized in the liver and undergoes first-pass metabolism.
Dosage & Administration
- Adults: 75-150 mg daily in 2 to 3 divided doses, preferably after food
- Children: 1-3 mg of diclofenac/kg body weight daily in divided doses
- Elderly patients: Lowest effective dosage recommended
- Maximum daily dose for suppository is 150 mg
- 1 ampoule of injection daily for adults
- 2-4 g of Diclofenac gel should be applied to the skin 3-4 times daily for external use
Interactions
- Increased plasma concentrations of lithium and digoxin
- Isolated reports of an increased risk of haemorrhage with the combined use of diclofenac and anticoagulant therapy
- Can be given together with oral antidiabetic agents without influencing their clinical effect
- Caution should be exercised when considering concomitant therapy of NSAID and quinolones
- Co-administration with other systemic NSAIDs and steroids may increase the frequency of unwanted effects
- Plasma levels of each is lowered with aspirin, although no clinical significance is known
Contraindications
- Hypersensitivity to any ingredient of the products
- Peptic ulcer
- Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
- Contra-indicated in asthmatic patients in whom attack with asthma, urticaria, or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
- Gel should not be used under occlusive airtight dressings
Side Effects
- Mild, rare, and transient adverse effects
- Epigastric pain
- Eructation
- Nausea
- Diarrhea
- Dizziness
- Headache
- Peripheral edema
- Skin reactions such as rash and eczema
- Local irritation and reddening of the skin
- Skin rash
Pregnancy & Lactation
- Employed only for compelling reasons during pregnancy
- Lowest effective dose should be used
- Not recommended during the first trimester of pregnancy
- Not recommended during lactation due to insufficient clinical data
Precautions & Warnings
- Close observation in patients with rare peptic ulceration or gastrointestinal bleeding
- Should not come in contact with eyes or mucus membranes
- Hands should be washed properly after application
- Not to be taken by mouth
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Store in a cool and dry place, protected from light. Store below 30°C. Keep out of the reach of children