Doxorin 400 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Doxophylline |
| Company | Opsonin pharma ltd |
| Also available as |
Product Title
- Doxorin
Categories
- Bronchodilator
- Methyl Xanthine Derivatives
Indications
- Bronchial asthma
- Bronchospasm
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary disease with spastic bronchial component
Pharmacology
- Novel bronchodilator
- Selective inhibition of phosphodiesterase 4
- Relaxes bronchial smooth muscle
- Decreased affinities toward adenosine A1 and A2 receptors
- Inhibition of platelet activating factor (PAF) and generation of leukotriene production
Dosage & Administration
- 200 mg tablet for elderly two or three times daily
- 400 mg tablet for adults two or three times daily
- 10 ml syrup for children >12 years of age
- 6-9 mg/kg body weight for children 6-12 years of age
- Doxophylline SR tablet for required daily dose of 400 mg
Interaction
- Not to be administered with other xanthine preparations
- Limit consumption of beverages and food containing caffeine
- Caution in administering with ephedrine or other sympathomimetic drugs
- Concurrent administration of erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, and propanolol may reduce hepatic clearance
- Phenytoin, other anticonvulsants, and cigarette smoking may increase clearance of xanthine derivatives
Contraindications
- Known hypersensitivity to the drug or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- Lactation
Side Effects
- Nausea
- Vomiting
- Epigastric pain
- Headache
- Irritability
- Insomnia
- Tachycardia
- Extrasystoles
- Tachypnea
- Hyperglycemia
- Albuminuria
- Severe cardiac arrhythmias in case of overdose
- Tonic-clonic seizure in case of overdose
Pregnancy & Lactation
- Animal tests show no interference with pre and postnatal growth
- Insufficient clinical evidence during pregnancy
- Contraindicated during lactation
Precautions & Warnings
- Factors that reduce hepatic clearance of xanthine derivatives can increase plasma levels
- Caution in patients with cardiac disease, hypertension, hypoxemia, hyperthyroidism, corpulmonale, congestive heart failure, liver disease, peptic ulcer, renal impairment
- Monitoring of blood levels recommended in cases of influence on drug clearance
Overdose Effects
- Severe cardiac arrhythmias
- Tonic-clonic seizure
- No specific antidote
Therapeutic Class
- Bronchodilator
- Methyl xanthine derivatives
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children
- Use only on prescription of specialist physician