Arbium 100 mg (Tablet)
Unit Price: ৳ 12.00 (30's pack: ৳ 360.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Asiatic laboratories ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
- Reduces vasoconstriction and release of aldosterone
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Total daily dose ranges from 25 mg to 100 mg
- Adjustments for patients with intravascular volume depletion
- Dose adjustments for patients over 75 years
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with concomitant use of hydrochlorothiazide
- Risk of increased serum potassium with potassium-sparing diuretics and supplements
- Potential attenuation of antihypertensive effect by non-steroidal anti-inflammatory drugs
Contraindications
- Contraindicated in pregnant women and patients hypersensitive to any component
- Not to be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects: dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects: fatigue, oedema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased fetal risk if administered during second or third trimester
- Unknown excretion in human milk
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death during second and third trimesters of pregnancy
- Risk of symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment needed in patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment or on dialysis
- Consider lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children