Torcin D 0.1%+0.3% (Ophthalmic Solution)

Indications

• Steroid responsive inflammatory ocular conditions
• Chronic anterior uveitis
• Corneal injury from chemical radiation or thermal burns
• Penetration of foreign bodies

Pharmacology

• Bactericidal activity of Tobramycin
• Inhibition of normal protein synthesis in susceptible bacteria
• Action on ribosome causing bacterial misreading of messenger RNA
• Inhibition of phospholipase A2 by Dexamethasone
• Inhibition of chemo-tactic infiltration of neutrophils into the site of inflammation

Dosage & Administration

• Eye Drops: 3-5 times per day into the conjunctival sac
• Increased dosage during the initial 24 to 48 hours
• Eye Ointment: 3-4 times per day into the conjunctival sac
• Pediatric Use: Safety and effectiveness not established below the age of 2 years

Interaction

• No specific interaction studies performed with Torcin D eye drops
• Interval of 10 minutes between successive applications for concomitant therapy

Contraindications

• Epithelial herpes simplex keratitis
• Vaccinia and varicella
• Mycobacterial infection of the eye
• Hypersensitivity to any component of the medication

Side Effects

• Hypersensitivity and localized ocular toxicity
• Lid itching, swelling and conjunctival erythema
• Elevation of intraocular pressure with possible development of glaucoma
• Optic nerve damage
• Posterior subcapsular cataract formation
• Delayed wound healing

Pregnancy & Lactation

• Use during pregnancy if potential benefit justifies the potent risk to the fetus
• Caution during nursing as systemic absorption to produce detectable quantities in human milk is unknown

Precautions & Warnings

• Consideration of fungal infections of the cornea after long-term steroid dosing
• Prolonged use may result in overgrowth of non-susceptible organisms
• Risk of cross-sensitivity to other aminoglycoside antibiotics

Overdose Effects

• No known overdose through local administration
• Specific measures to reduce resorption in case of accidental oral intake
• No specific antidote

Therapeutic Class

Ophthalmic steroid - antibiotic combined preparations

Storage Conditions

Store at room temperature. Close the bottle immediately after use. Do not use for longer than one month after opening the bottle.

Related Brands

• Torcin D 0.1%+0.3% (Ophthalmic Ointment) - opsonin-pharma-ltd
• Tomin-D 0.1%+0.3% (Ophthalmic Solution) - kemiko-pharmaceuticals-ltd
• Tobram-D 0.1%+0.3% (Ophthalmic Solution) - pacific-pharmaceuticals-ltd
• Tobracin D 0.1%+0.3% (Ophthalmic Ointment) - osl-pharma-limited
• Tobracin D 0.1%+0.3% (Ophthalmic Solution) - osl-pharma-limited