NX Plus 500 mg+20 mg (Tablet (Delayed Release))

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)

Strip Price: ৳ 150.00

Medicine Details

Category	Details
Generic	Naproxen sodium esomeprazole magnesium
Company	One pharma ltd
Also available as	Nx plus 375 mg tablet

Relief of signs and symptoms of osteoarthritis
Relief of signs and symptoms of rheumatoid arthritis
Relief of signs and symptoms of ankylosing spondylitis
Decrease the risk of developing gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals
Adult dosage: one tablet twice daily of either 375 mg naproxen/20 mg of esomeprazole or 500 mg naproxen/20 mg of esomeprazole
Juvenile Idiopathic Arthritis in Adolescent Patients 12 Years of Age & Older dosage: based on weight

Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics & beta-blockers
Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication
Esomeprazole inhibits gastric acid secretion
Esomeprazole may interfere with the absorption of drugs
Administration with high-fat food does not affect the extent of absorption of naproxen

Known hypersensitivity to any component of this tablet or substituted benzimidazoles
History of asthma, urticaria or other allergic-type reactions after taking aspirin or other NSAIDs
Use during the peri-operative period in the setting of coronary artery bypass graft (CABG) surgery

Naproxen and Esomeprazole tablet has been shown to decrease the occurrence of gastric ulcers & NSAID associated upper gastrointestinal adverse events compared to Naproxen alone
Gastrointestinal side effects from Naproxen are decreased
Naproxen may be associated with a small increased risk of arterial thrombotic events, oedema, hypertension, cardiac failure, gastrointestinal adverse events
The most commonly observed adverse events are gastrointestinal in nature
Peptic ulcers, perforation or GI bleeding may occur
Nausea, vomiting, diarrhea, flatulence, constipation, dyspepsia, abdominal pain, melaena, haematemesis, ulcerative stomatitis, exacerbation of colitis and Crohn’s disease have been reported

Naproxen and Esomeprazole tablet should not be given unless the potential benefit to the patient outweighs the potential risk to the fetus
Naproxen and Esomeprazole tablet is contraindicated during the third trimester of pregnancy
Naproxen and Esomeprazole tablet should not be used during breastfeeding
The use of NSAIDs like Naproxen may impair female fertility
The use of Naproxen and Esomeprazole tablet is not recommended in women attempting to conceive

The combination of Naproxen and Esomeprazole tablet and NSAIDs including cyclooxygenase-2 selective inhibitors should be avoided
Low dose acetylsalicylic acid can be used with Naproxen and Esomeprazole tablet
Risk-factors to develop NSAID related gastro-intestinal complications should be considered
Elderly people have an increased frequency of adverse reactions
Gastrointestinal bleeding, ulceration or perforation can occur
Caution should be advised in patients receiving NSAIDs with concomitant medications
Appropriate monitoring and advice are required for patients with a history of hypertension and/or mild to moderate congestive heart failure
Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury

Use caution when high doses are required in elderly patients
Naproxen-containing products are not recommended for use in patients with moderate to severe or severe renal impairment
Monitor patients with mild to moderate hepatic impairment closely

Symptoms related to Naproxen overdose: lethargy, dizziness, drowsiness, epigastric pain, gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, coma
Management: Symptomatic and supportive care following a NSAID overdose
Related to Esomeprazole: transient symptoms