Onepro 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company One pharma ltd
Also available as
Onepro 20 mg capsule Onepro 20 mg tablet Onepro 40 mg tablet

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Selective inhibition of the H+/K+-ATPase
  • Increased acid control compared to racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Absorption occurs approximately 1.5 hours after oral administration
  • Extensively metabolized in the liver
  • Plasma elimination half-life of approximately 1–1.5 hours
  • Systemic bioavailability of approximately 90%
  • 97% bound to plasma proteins
  • Metabolism primarily dependent on CYP2C19 isoenzyme
  • Combination therapy with antimicrobials

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Different dosages for various indications
  • Dosage adjustments for pediatric patients
  • Dosage adjustments for patients with hepatic insufficiency
  • Dosage adjustments for patients with renal insufficiency

Administration

  • Tablet or capsule should be swallowed whole
  • Oral suspension administration instructions
  • IV Injection preparation and administration instructions

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • Limited interaction with CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • Potential interference with gastric pH-dependent drug absorption
  • No clinically significant interactions with specific drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if esomeprazole use is considered essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific administration instructions for patients with difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy between elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Acute toxicity symptoms in animals
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions

  • Description of Onepro 40 mg Capsule
  • Multiple uses of Onepro 40 mg Capsule
  • Common side effects of Onepro 40 mg Capsule
  • Use during pregnancy or breastfeeding
  • Time to onset of action
  • Quick tips for using Onepro 40 mg Capsule

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