Cozaril 50 mg (Tablet)
Unit Price: ৳ 4.03 (30's pack: ৳ 120.90)
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Hallmark pharmaceuticals ltd |
Therapeutic Class
- Angiotensin-II receptor blocker
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Dosage & Administration
- Usual starting and maintenance dose of 50mg once daily
- 25mg twice daily if 50mg once daily is inadequate
- 25mg once daily for patients with intravascular volume-depletion
- Lower starting dose of 25mg once daily for patients over 75 years
- Total daily dose ranges from 25mg to 100mg
- No initial dosage adjustment for patients up to 75 years
Interaction
- Reduction of active metabolite levels by rifampicin and fluconazole
- Potentiation of antihypertensive effects with concomitant use of hydrochlorothiazide
- Increased serum potassium with concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes
- Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
- Increased risk of renal impairment with use of ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic at the same time
Contraindications
- Pregnant women
- Patients hypersensitive to any component
- Co-administration with aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Upper respiratory infection
- Fatigue
- Oedema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Category D in pregnancy
- Risk to fetus in second or third trimesters
- Potential excretion in human milk
- Consideration for discontinuation of nursing or drug
Precautions & Warnings
- Reduction of fetal renal function and increase in fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment (creatinine clearance 20-50ml/min)
- Lower starting dose for patients with moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with history of hepatic impairment
- Administration with other antihypertensive agents
- Contraindications in pregnancy and in patients hypersensitive to losartan
Mode of Action
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues and reduces vasoconstriction and aldosterone release responsible for hypertension
Precautions
- Use in hepatic impairment
- Avoid use with potassium-sparing diuretics
- Increase in blood urea and serum creatinine in patients with bilateral renal artery stenosis or solitary kidney artery
- Reversible changes in renal function upon discontinuation of therapy
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children