G-Losartan 25 mg (Tablet)
Unit Price: ৳ 3.00 (3 x 10: ৳ 90.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Gonoshasthaya pharma ltd |
| Also available as |
Indications
- Treatment of Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily recommended if 50 mg once daily is inadequate
- 25 mg once daily recommended for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily recommended for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce levels of active metabolite
- Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
- Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes may lead to increases in serum potassium
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic at the same time
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Not to be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to fetus increases if administered during second or third trimesters
- Unknown excretion in human milk
- Consideration to discontinue nursing or drug, taking into account importance to mother
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Reported changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Consider lower dose for patients with a history of hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children