G-Albendazole 400 mg (Chewable Tablet)

Unit Price: ৳ 3.45 (10 x 10: ৳ 345.00)
Strip Price: ৳ 34.50

Medicine Details

Category Details
Generic Albendazole
Company Gonoshasthaya pharma ltd

Indications

  • Hookworm infestation
  • Roundworm infestation
  • Threadworm infestation
  • Whipworm infestation
  • Strongyloides infestation
  • Tapeworm infestation
  • Opisthorchi infestation
  • Hydatid disease

Description

G-G-Albendazole is a benzimidazole anthelmintic, active against most nematodes and some cestodes. It is used in the treatment of intestinal nematode infections and in higher doses in the treatment of hydatid disease. G-G-Albendazole exhibits vermicidal, ovicidal, and larvicidal activity. The principal mode of action of G-G-Albendazole is its inhibitory effect on tubulin polymerization, which results in the loss of cytoplasmic microtubules.

Pharmacology

Broad spectrum anthelmintic with vermicidal, ovicidal, and larvicidal activities. Thought to exert its effect by blocking glucose uptake in helminths, leading to depletion of energy levels and subsequent parasite immobilization. Extensively metabolized, probably in the liver. Poorly absorbed from the gastrointestinal tract.

Dosage & Administration

  • 400 mg as a single dose for various infestations in adults and children over 2 years
  • 200 mg for children of 1-2 years
  • Not recommended for children under 1 year
  • 400 mg twice daily for 28 days for hydatid disease, with variations based on patient weight and type of echinococcosis
  • 400 mg once daily for 5 days in giardiasis

Interaction

No reported pharmacodynamic or pharmacokinetic interactions involving G-G-Albendazole.

Contraindications

  • Not recommended for neonates
  • Consider dose reduction for children weighing less than 10 kg
  • Avoid use in pregnant women
  • No evidence for dose alteration in renal, hepatic, or cardiac failure

Side Effects

  • Gastrointestinal disturbances
  • Headache
  • Dizziness
  • Changes in liver enzymes
  • Rarely reversible alopecia
  • Rash
  • Fever
  • Blood disorders including leucopenia and pancytopenia
  • Allergic shock if cyst leakage
  • Convulsion and meningism in cerebral disease

Pregnancy & Lactation

Albendazole is FDA Pregnancy category C. It should be avoided in pregnancy and lactation unless the potential benefits outweigh the possible risks to the fetus.

Precautions & Warnings

  • Blood counts and liver function tests before treatment and twice during each cycle
  • Considerations for breastfeeding women
  • Pregnancy exclusion before treatment
  • Constant medical supervision in the treatment of Echinococcosis with regular monitoring of serum-transaminase concentrations and of leucocyte and platelet counts

Therapeutic Class

Anthelmintic

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

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