Asixone 1 gm/vial (IM Injection)

1 gm vial: ৳ 190.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Asiatic laboratories ltd
Also available as
Asixone 1 gm injection Asixone 250 mg injection Asixone 250 mg injection Asixone 500 mg injection Asixone 500 mg injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. Ceftriaxone kills bacteria by interfering with the synthesis of the bacterial cell wall. It has a long plasma elimination half-life of about 6 to 9 hours and is highly protein bound (95%).

Dosage

  • Adult:
    • 1 to 2 gm by intravenous or intramuscular administration once a day
    • Maximum dose: 4 gm/day
  • Infants and Children:
    • 50 to 75 mg/kg intravenous or intramuscular administration once a day
    • Maximum dose: 2 gm/day
  • Duration of therapy: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days.

Administration

  • Intramuscular Injection: Dissolve in Lidocaine HCI 1%
  • Intravenous Injection:
    • Dissolve in Water for injection
    • Administration over 2-4 minutes

Interaction

No drug interactions reported

Contraindications

Not for patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia
  • Hepatic reactions including elevations of SGOT or SGPT
  • CNS reactions including nervousness, confusion, sleep disturbances

Pregnancy & Lactation

Not established for safety in human pregnancy. Caution in lactating mothers

Precautions & Warnings

  • Anaphylactic shock possible
  • Check blood picture during prolonged treatment

Use in Special Populations

Do not give to neonates if premature and newborn (up to 28 days of age)

Overdose Effects

No specific antidote. Treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children

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