Larb 25 mg (Tablet)
Unit Price: ৳ 4.51 (3 x 14: ৳ 189.42)
Strip Price: ৳ 63.14
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Acts on AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Can be used alone or in combination with other antihypertensive agents
- Total daily dose ranges from 25 mg to 100 mg
Interaction
- Reduced active metabolite levels with rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Risk of increased serum potassium with potassium-sparing diuretics or supplements
Contraindications
- Contraindicated in pregnant women
- Hypersensitivity to any component of the product
- Should not be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases if administered during second or third trimester
- Unknown excretion in human milk
Precautions & Warnings
- Reduces fetal renal function and increases fetal and neonatal morbidity and death when used in second and third trimesters of pregnancy
- Symptomatic hypotension may occur in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
Use in Special Populations
- No initial dosage adjustment for patients with mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Lower dose recommended for patients with history of hepatic impairment
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children