Clogfree 75 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Clopidogrel bisulphate
Company Asiatic laboratories ltd

Indications

  • Reduction of myocardial infarction rate
  • Reduction of stroke rate
  • Treatment of acute coronary syndrome
  • Treatment of non-ST-segment elevation ACS
  • Treatment of ST-elevation myocardial infarction
  • Treatment of recent MI
  • Treatment of recent stroke
  • Treatment of established peripheral arterial disease

Pharmacology

  • Prodrug
  • Inhibition of platelet activation
  • Irreversible binding to P2Y12 class of ADP receptors on platelets
  • Dose-dependent inhibition of platelet aggregation
  • Rapid onset of action
  • Steady-state inhibition between Day 3 and Day 7

Dosage & Administration

  • Oral administration
  • Loading dose of 300 mg for acute coronary syndrome
  • Maintenance dose of 75 mg once daily
  • Fast onset with loading dose
  • Administration with or without food

Interaction

  • Risk of bleeding with NSAIDs, warfarin, SSRIs, SNRIs
  • Avoid concomitant use with CYP2C19 inhibitors
  • Increased plasma concentrations of Repaglinide with concomitant use

Contraindications

  • Hypersensitivity to the drug substance or any component
  • Active pathological bleeding such as peptic ulcer or intracranial hemorrhage

Side Effects

  • Common side effects: bleeding, diarrhea, gastrointestinal discomfort, hemorrhage, skin reactions
  • Rare side effects: acquired hemophilia, anemia, angioedema, arthralgia, bone marrow disorders

Pregnancy & Lactation

  • Use during pregnancy only if clearly needed
  • Unknown excretion in human breast milk
  • Consideration for discontinuing nursing

Precautions & Warnings

  • Impaired metabolism in CYP2C19 poor metabolizers
  • Reduced antiplatelet activity with concomitant use of CYP2C19 inhibitors
  • Increased risk of bleeding due to lifelong platelet aggregation inhibition
  • Discontinuation risk for cardiovascular events
  • Reported cases of TTP requiring urgent treatment
  • Hypersensitivity reactions reported

Use in Special Populations

  • Safety and effectiveness not established in pediatric populations
  • No dosage adjustment necessary in elderly patients

Overdose Effects

  • May lead to bleeding complications
  • Platelet transfusion may restore clotting ability

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep below 30°C temperature
  • Store in a dry place
  • Protect from light
  • Do not freeze
  • Keep out of the reach of children

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