Larb 100 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to the AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily for inadequate antihypertensive effect
- 25 mg once daily for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose of 25 mg once daily for patients over 75 years
Interaction
- Reduction of active metabolite levels by Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increased serum potassium with potassium-sparing diuretics, supplements, or salt substitutes
- Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
- Increased risk of renal impairment with concomitant use of certain drugs
Contraindications
- Pregnant women
- Hypersensitivity to any component of the product
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Dizziness
- Diarrhea
- Nasal congestion
- Cough
- Fatigue
- Oedema
- Abdominal pain
- Chest pain
- Nausea
- Headache
- Pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Increased risk to fetus if administered during second or third trimesters
- Unknown excretion in human milk
- Consideration of drug discontinuation during nursing
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure reported in renal-impaired patients
Use in Special Populations
- No initial dosage adjustment in patients with mild renal impairment
- Lower starting dose for patients with moderate to severe renal impairment
- Use caution in patients with intravascular volume depletion
- Consideration of lower dose for patients with a history of hepatic impairment
- Contraindicated in pregnancy and in patients hypersensitive to losartan
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children