Esomiloc 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Kumudini pharma ltd
Also available as
Esomiloc 20 mg tablet Esomiloc 20 mg capsule Esomiloc 40 mg tablet

Title

  • Esomiloc 40 mg Capsule

Categories

  • Medicine
  • Proton Pump Inhibitor
  • Gastrointestinal Medication

Description

  • Esomeprazole is indicated for relieving chronic heartburn symptoms and other symptoms associated with GERD
  • It is also used for the healing of erosive esophagitis and for maintenance of healing of erosive esophagitis
  • In combination with amoxicillin and clarithromycin for eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • It is indicated for Zollinger-Ellison Syndrome, Acid-related Dyspepsia, Duodenal & Gastric ulcer

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid-related Dyspepsia
  • Healing of Duodenal & Gastric ulcers

Pharmacology

  • Proton pump inhibitor that suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Peak plasma levels (Cmax) occur at approximately 1.5 hours (Tmax)
  • Esomeprazole capsules contain an enteric-coated pellet formulation of esomeprazole magnesium
  • Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours
  • Dose-dependent pharmacokinetics
  • Combination therapy with antimicrobials
  • First-line treatment for H. pylori infection
  • Comprehensive distribution and excretion properties

Dosage

  • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
  • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily
  • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • Helicobacter Pylori Eradication: Triple Therapy for 10 days
  • Zollinger-Ellison Syndrome: 20-80 mg Once Daily
  • Acid-related Dyspepsia: 20-40 mg Once Daily for 2-4 weeks
  • Dosage adjustment for IV Injection or IV infusion based on patient age and weight
  • Risk reduction of rebleeding of Gastric or Duodenal Ulcers

Administration

  • Oral dosage form and Oral Suspension administration instructions
  • IV Injection solution preparation and administration guidelines

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • Inhibition of CYP2C19 by Esomeprazole
  • No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
  • Potential interference with drug absorption related to gastric pH
  • Effect on CYP2C19 substrates such as diazepam
  • Increased plasma levels of clarithromycin and Esomeprazole during combination therapy

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Common adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth
  • Similar adverse event profile in short term and maintenance treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects observed in animal studies
  • Excretion of esomeprazole in milk not studied
  • Breastfeeding should be discontinued if essential use of esomeprazole is considered

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking Esomeprazole
  • Long-term use and associated risks

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy observed between elderly and younger individuals
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency
  • Pharmacokinetics not altered in patients with renal impairment

Overdose Effects

  • Reports of lethal overdose in animal studies
  • Acute signs of toxicity include reduced motor activity, respiratory changes, tremor, and convulsions
  • No specific antidote for Esomeprazole
  • Symptomatic and supportive treatment recommended for overdosage

Storage Conditions

  • Temperature and environmental storage guidelines
  • Protection from light and moisture
  • Safety measures to keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure visualization provided

Common Questions about Esomiloc 40 mg Capsule

  • Overview of Esomiloc 40 mg Capsule
  • Uses and indications
  • Common side effects
  • Pregnancy and breastfeeding considerations
  • Onset of action and quick tips for users

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