LK 25 mg (Tablet)
Unit Price: ৳ 4.50 (3 x 10: ৳ 135.00)
Strip Price: ৳ 45.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Orally active angiotensin II receptor blocker
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- Total daily dose ranges from 25 mg to 100 mg
- Different dosage recommendations for patients over 75 years
- Advice for patients with intravascular volume-depletion
Interaction
- Reduced levels with Rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Potential increases in serum potassium with potassium-sparing diuretics or supplements
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnant women
- Hypersensitivity to any component of the product
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects like fatigue, edema, and abdominal pain
Pregnancy & Lactation
- Pregnancy Category D
- Risk to the fetus if administered during the second or third trimesters
- Unknown excretion in human milk
- Consideration for discontinuation of nursing or drug based on importance to the mother
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death in second and third trimesters of pregnancy
- Risk of symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Reported changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment for patients with mild renal impairment
- Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
- Consideration of lower dose for patients with hepatic impairment
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children