LK 50 mg (Tablet)

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Losartan potassium
Company Pacific pharmaceuticals ltd
Also available as
Lk 25 mg tablet

Indications

  • Hypertension
  • Renal Protection in Type-2 Diabetic Patients with Proteinuria

Pharmacology

  • First non-peptide orally active angiotensin II receptor blocker
  • Binds to AT1 receptor in vascular smooth muscle, adrenal gland, kidneys, and heart
  • Reduces vasoconstriction and aldosterone release

Dosage & Administration

  • Usual starting and maintenance dose is 50 mg once daily
  • 25 mg twice daily recommended if 50 mg is inadequate
  • Starting dose of 25 mg once daily for patients with intravascular volume depletion
  • Total daily dose ranges from 25 mg to 100 mg
  • Lower starting dose of 25 mg once daily recommended for patients over 75 years

Interaction

  • Rifampicin and fluconazole reduce levels of active metabolite
  • Concomitant use with hydrochlorothiazide may potentiate antihypertensive effects
  • Concomitant use with potassium-sparing diuretics, potassium supplements, or salt substitutes may increase serum potassium
  • Attenuation of antihypertensive effect by non-steroidal anti-inflammatory drug indomethacin
  • Increased risk of renal impairment with combined use of ACE-inhibitor, angiotensin receptor antagonist, anti-inflammatory drug, and thiazide diuretic

Contraindications

  • Pregnant women
  • Patients hypersensitive to any component of the product
  • Concomitant administration with Aliskiren in patients with diabetes

Side Effects

  • Dizziness
  • Diarrhea
  • Nasal congestion
  • Cough
  • Upper respiratory infection
  • Fatigue
  • Edema
  • Abdominal pain
  • Chest pain
  • Nausea
  • Headache
  • Pharyngitis

Pregnancy & Lactation

  • Pregnancy Category D
  • Increased risk to fetus if administered during second or third trimesters
  • Consideration for discontinuing nursing

Precautions & Warnings

  • Reduction of fetal renal function and increase in fetal and neonatal morbidity and death when used in second and third trimesters of pregnancy
  • Symptomatic hypotension in intravascularly volume-depleted patients
  • Significantly increased plasma concentration in cirrhotic patients
  • Changes in renal function including renal failure reported in renal impaired patients

Use in Special Populations

  • No initial dosage adjustment necessary in patients with mild renal impairment
  • Lower starting dose recommended for patients with moderate to severe renal impairment or on dialysis
  • Consideration for lower dose in patients with a history of hepatic impairment

Therapeutic Class

  • Angiotensin-ll receptor blocker

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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