Metle 500 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Metformin hydrochloride
Company Apex pharmaceuticals ltd

Indications

  • Treatment of type 2 diabetes mellitus
  • Management of diabetes in overweight patients
  • Reduction of diabetic complications
  • Monotherapy for adults
  • Combination therapy with other oral antidiabetic agents or insulin
  • Therapy for children from 10 years of age and adolescents

Pharmacology

  • Biguanide type oral antihyperglycemic drug
  • Lowers basal and postprandial plasma glucose
  • Different mechanism of action from sulfonylureas
  • Does not produce hypoglycemia
  • Decreases hepatic glucose production
  • Improves insulin sensitivity

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerance
  • Usual starting dose for adults - 500 mg twice a day or 850 mg once a day
  • Usual starting dose for children - 500 mg twice a day
  • Dosage increases in increments of 500 mg or 850 mg
  • Maximum daily doses
  • Instructions for Metformin immediate release tablet
  • Instructions for Metformin extended release tablet
  • Special considerations for renal impaired patients

Interaction

  • No chronic co-administration information with Furosemide
  • Enhancement of Nifedipine absorption
  • Potential interaction with cationic drugs
  • No effect on Cimetidine pharmacokinetics
  • List of drugs that may affect glycemic control

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Acute metabolic acidosis
  • Severe renal failure
  • Conditions altering renal function or causing tissue hypoxia

Side Effects

  • Hemolytic anemia
  • Lactic acidosis
  • Decrease of vitamin B12 absorption
  • Peripheral neuropathy in patients with vitamin B12 deficiency
  • Taste disturbance
  • Encephalopathy
  • Gastrointestinal disorders
  • Liver function test abnormalities or hepatitis
  • Skin reactions

Pregnancy & Lactation

  • Increased risk of congenital abnormalities and perinatal mortality with uncontrolled diabetes during pregnancy
  • Recommendation of insulin use during pregnancy
  • Excretion into human breast milk
  • Limited data on breastfeeding safety

Precautions & Warnings

  • Substantial excretion by the kidney
  • Potential for lactic acidosis and Metle accumulation
  • Decreased vitamin B12 level
  • Increased risk of hypoglycemia
  • Monitoring of renal function
  • Discontinuation before surgery
  • Caution in conditions causing dehydration or serious infections
  • Annual estimation of Vitamin B-12 levels
  • Monitoring blood glucose during combined therapy
  • Adjustment of Metle dosage during co-administration with certain drugs

Use in Special Populations

  • Adjustment of metformin dosage in elderly subjects
  • No effect on growth and puberty detected in controlled clinical studies
  • Careful follow-up on metformin effect in children
  • Caution in prescribing to children aged between 10 and 12 years
  • Regular assessment of renal function
  • Special caution in situations affecting renal function

Overdose Effects

  • No observed hypoglycemia with Metle doses up to 85 gm
  • Occurrence of lactic acidosis in such circumstances
  • Treatment with hemodialysis in case of lactic acidosis

Therapeutic Class

  • Biguanides

Storage Conditions

  • Keep below 30°C temperature
  • Protected from light & moisture
  • Keep out of the reach of children

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