Kflam 60 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 95.33 (1 x 3: ৳ 286.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Apex pharmaceuticals ltd
Also available as
Kflam 10 mg tablet Kflam 30 mg injection

Indications

  • Short-term management of moderate to severe post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins and acts as a peripherally acting analgesic
  • Biologically active form is the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Metabolites and some unchanged drug excreted in urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits cyclooxygenase enzyme system and prostaglandin synthesis
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection: Single or multiple doses, for acute pain management
  • IM administration should be given slowly and deeply into the muscle
  • Analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM
  • Duration of analgesic effect is usually 4 to 6 hours
  • Different doses for different age groups and conditions
  • Eye Drops: Adults - 1 drop in each eye 4 times daily

Interaction

  • Increases side effects with other NSAIDs or aspirin
  • Enhances anti-coagulant effect with anti-coagulants
  • Reduces anti-hypertensive effect with Beta Blockers
  • Increases risk of renal impairment with ACE Inhibitors
  • Enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Not for use in children under 16 years of age
  • Contraindicated as a prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in female
  • Pulmonary edema

Pregnancy & Lactation

  • Category C for US FDA
  • Avoid use in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Exercise caution in patients over 65 years
  • Exercise caution in patients with active/suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use and monitor for corneal health in patients with corneal epithelial breakdown when using topical NSAIDs

Therapeutic Class

  • Rheumatoid Arthritis Drugs
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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