Lok-50 50 mg (Tablet)
Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Globe pharmaceuticals ltd |
Indications
- Treatment of hypertension
- Renal protection in type-2 diabetic patients with proteinuria
Pharmacology
- First non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor
- Reduces vasoconstriction
- Reduces release of aldosterone
Dosage & Administration
- Usual starting and maintenance dose of 50 mg
- 25 mg twice daily if 50 mg once daily is inadequate
- Starting dose of 25 mg once daily for patients with intravascular volume-depletion
- Total daily dose ranges from 25 mg to 100 mg
- No initial dosage adjustment for patients up to 75 years
- Lower starting dose of 25 mg once daily for patients over 75 years
Interaction
- Reduced levels with rifampicin and fluconazole
- Potentiation of antihypertensive effects with hydrochlorothiazide
- Increases in serum potassium with potassium-sparing diuretics, supplements or salt substitutes containing potassium
- Attenuation by indomethacin
- Increased risk of renal impairment with multiple drug use
Contraindications
- Contraindicated in pregnant women
- Contraindicated in patients hypersensitive to any component
- Not to be administered with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk to the fetus
- Unknown excretion in human milk
- Consideration for discontinuation of nursing or drug
Precautions & Warnings
- Reduction in fetal renal function during second and third trimesters of pregnancy
- Symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Changes in renal function including renal failure in renal impaired patients
Use in Special Populations
- No initial dosage adjustment for mild renal impairment
- Lower starting dose for moderate to severe renal impairment or patients on dialysis
- Lower dose for patients with hepatic impairment
- Administered with or without food
Therapeutic Class
- Angiotensin II receptor blocker
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children