Erazole 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 8.00 (5 x 6: ৳ 240.00)
Strip Price: ৳ 48.00

Medicine Details

Category Details
Generic Esomeprazole
Company Kemiko pharmaceuticals ltd
Also available as
Erazole 20 mg tablet Erazole 40 mg capsule Erazole 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal and Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Metabolized in the liver by cytochrome P450 (CYP) enzyme system
  • Extensive metabolism
  • Plasma protein binding is constant over a specific concentration range
  • Low urine excretion

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Dosage for healing of erosive esophagitis
  • Dosage for symptomatic GERD
  • Dosage for Helicobacter pylori eradication
  • Dosage for Zollinger-Ellison Syndrome
  • Dosage for Acid-related Dyspepsia
  • Dosage for Duodenal and Gastric ulcer
  • Pediatric dosage variations based on body weight
  • Adult dosage for risk reduction of rebleeding of Gastric or Duodenal Ulcers

Administration

  • Tablet or capsule administration
  • Oral Suspension administration
  • IV Injection administration
  • Guidelines for administration through nasogastric or gastric tube

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition of gastric acid secretion may interfere with drug absorption
  • Co-administration with clarithromycin may increase plasma levels
  • No significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion of esomeprazole in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude presence of gastric malignancy
  • Guidelines for patients with difficulty swallowing capsules
  • Use of antacids while taking Erazole

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Lethal dose in rats
  • Signs of acute toxicity
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Erazole 40 mg Tablet

  • Proton pump inhibitor reducing stomach acid production
  • Multiple uses including treating GERD and ulcers
  • Common side effects
  • Usage during pregnancy or breastfeeding
  • Onset of action
  • Quick Tips for usage

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