Pepzol 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (6 x 10: ৳ 420.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Leon pharmaceuticals ltd
Also available as
Pepzol 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Dosage

  • 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
  • 20 mg Once Daily for maintenance of healing of erosive esophagitis
  • 20 mg Once Daily for Symptomatic GERD
  • Triple Therapy for Helicobacter Pylori eradication
  • 20-80 mg Once Daily for Zollinger-Ellison Syndrome
  • 20-40 mg Once Daily for Acid-related Dyspepsia
  • 20 mg Once Daily for 2-4 weeks for Duodenal ulcer
  • 20-40 mg Once Daily for 4-8 weeks for Gastric ulcer
  • IV Injection or IV infusion as per specified dosage for adults and pediatric patients

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Systemic bioavailability is approximately 90% after repeated once daily dosing

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be stirred well and taken within 30 minutes
  • IV Injection should be administrated over a period of at least 3 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with specific drugs metabolized by CYP enzymes

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Insufficient data in pregnant women
  • No studies on excretion in milk
  • Discontinue breastfeeding if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients to swallow capsules and use antacids

Use in Special Populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy in geriatric use
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency

Overdose Effects

  • Signs of acute toxicity in rats
  • No specific antidote known
  • Expected to be removed by dialysis
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

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