Pepzol 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Leon pharmaceuticals ltd
Also available as
Pepzol 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Extensive metabolism in the liver by the cytochrome P450 enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours
  • Combination therapy with antimicrobials

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Different dosages for various conditions
  • Different dosages for adults and pediatric patients
  • Specific dosage durations for different indications

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension administration procedure
  • IV Injection administration procedure

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with specific drugs
  • Potential interference with the absorption of certain drugs
  • No clinically significant interactions with specific drugs

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealed no teratogenic effects
  • Excretion of esomeprazole in milk not studied
  • Breast-feeding should be discontinued if esomeprazole use is essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Specific administration instructions for patients with difficulty swallowing capsules
  • Use of antacids while taking Pepzol

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal dose to rats
  • Major signs of acute toxicity
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure image available

Common Questions about Pepzol 40 mg Capsule

  • Purpose of Pepzol 40 mg Capsule
  • Uses for Pepzol 40 mg Capsule
  • Common side effects of Pepzol 40 mg Capsule
  • Safety during pregnancy and breastfeeding
  • Onset of action for Pepzol 40 mg Capsule
  • Quick Tips for taking Pepzol 40 mg Capsule

Related Brands