Alcavir 0.5 mg (Tablet)
Unit Price: ৳ 45.00 (2 x 10: ৳ 900.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Entecavir |
| Company | Albion laboratories limited |
Indications
- Treatment of chronic hepatitis B virus infection in adults
- Treatment of chronic hepatitis B virus infection in pediatric patients 2 years of age and older
- With evidence of active viral replication
Pharmacology
- Competes with natural substrate deoxyguanosine triphosphate
- Functionally inhibits all three activities of the HBV polymerase
- Base priming
- Reverse transcription of the negative strand from the pregenomic messenger RNA
- Synthesis of the positive strand of HBV DNA
Dosage & Administration
- Recommended dose of Entecavir for chronic hepatitis B virus infection in nucleoside-treatment-naive adults and adolescents 16 years of age is 0.5 mg once daily
- Recommended dose of Entecavir for Lamivudine-refractory or known Lamivudine or Telbivudine resistance mutations is 1 mg once daily
- Recommended dose of Entecavir for patients with decompensated liver disease (adult) is 1 mg once daily
Interaction
- Co-administration of Alcavir with Lamivudine or Adefovir dipivoxil did not result in significant drug interactions
Contraindications
- Contraindicated in patients with previously demonstrated hypersensitivity to Entecavir
Side Effects
- Most common adverse events are headache, fatigue, dizziness, and nausea
Pregnancy & Lactation
- No data on the effect of Entecavir on the transmission of HBV from mother to infant
- Not known whether it is excreted in human milk
- Mothers should be instructed not to breastfeed if they are taking Entecavir
Precautions & Warnings
- Lactic acidosis and severe hepatomegaly with steatosis have been reported with the use of nucleoside analogues alone or in combination with antiretrovirals
- Exacerbations of hepatitis after discontinuation of treatment
Use in Special Populations
- Safety and effectiveness of Alcavir in pediatric patients below the age of 2 years have not been established
- Care should be taken in dose selection for geriatric patients
- Dose adjustment is recommended for patients with renal impairment
Overdose Effects
- No experience of Alcavir overdosage reported in patients
- Healthy subjects who received up to 20 mg daily for up to 14 days and single doses up to 40 mg had no unexpected adverse events
Therapeutic Class
- Hepatic viral infections (Hepatitis B)
Storage Conditions
- Keep in a dry place
- Store below 30°C
- Protect from light
- Keep out of the reach of children