Esofour 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 7.20 (5 x 14: ৳ 504.00)
Strip Price: ৳ 100.80

Medicine Details

Category Details
Generic Esomeprazole
Company Albion laboratories limited
Also available as
Esofour 40 mg tablet Siligel 20 mg capsule Siligel 40 mg capsule

Title

  • Esofour 20 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • A proton pump inhibitor for relieving chronic heartburn symptoms and other conditions

Indications

  • Relieve chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Acid-related Dyspepsia
  • Treatment of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Peak plasma levels at approximately 1.5 hours after oral administration
  • Extensive metabolism in the liver
  • 97% bound to plasma proteins
  • Approximately 1-1.5 hours plasma elimination half-life
  • Excretion of less than 1% in the urine

Dosage

  • 20 mg or 40 mg once daily for healing of erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for symptomatic GERD
  • Triple therapy for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for acid-related dyspepsia
  • 20 mg once daily for 2-4 weeks for duodenal ulcer
  • 20-40 mg once daily for 4-8 weeks for gastric ulcer
  • IV injection or infusion for various conditions based on patient age and weight

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension instructions
  • IV injection preparation and administration

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Unlikely to inhibit certain CYP enzymes
  • Potential interference with drugs influenced by gastric pH
  • Limited clinically significant interactions with other drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side effects

  • Common adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth

Pregnancy and lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions and warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Instructions for patients, including alternative oral administration method and allowance for antacids use

Special populations

  • Safety and effectiveness not established in pediatric patients
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose effects

  • Acute toxicity signs observed in rats
  • No reports of overdose in humans
  • No specific antidote known
  • Symptomatic and supportive treatment recommended
  • Possibility of multiple drug ingestion should be considered

Storage conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image URL: <URL>

Commonly asked questions

  • Standard usage information and commonly asked questions about Esofour 20 mg Tablet

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