Esofour 40 mg (Tablet (Enteric Coated))
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole |
| Company | Albion laboratories limited |
| Also available as |
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Treatment of Zollinger-Ellison Syndrome
- Management of acid-related Dyspepsia
- Treatment of Duodenal & Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppresses gastric acid secretion
- Specific inhibition of the H+/K+-ATPase
- Better acid control than racemic proton pump inhibitors
- Absorption within 1.5 hours after oral administration
- Metabolized in the liver by the cytochrome P450 enzyme system
- Plasma elimination half-life of approximately 1-1.5 hours
Dosage
- 20 mg or 40 mg Once Daily for Healing of Erosive Esophagitis
- 20 mg Once Daily for Maintenance of Healing of Erosive Esophagitis
- 20 mg Once Daily for Symptomatic GERD
- Triple Therapy for Helicobacter Pylori eradication
- 20-80 mg Once Daily for Zollinger-Ellison Syndrome
- 20-40 mg Once Daily for Acid-related Dyspepsia
- 20 mg Once Daily for Duodenal ulcer
- 20-40 mg Once Daily for Gastric ulcer
Administration
Tablet or capsule should be swallowed whole and taken one hour before a meal; Oral Suspension to be taken with water and stirred well; IV Injection to be administered over a specific period of time
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
- Potentially interferes with CYP2C19
- No clinically significant interactions with certain drugs like phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
Contraindications
Contraindicated in patients with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
No adequate and well-controlled studies in pregnant women; Not studied for excretion in breast milk; Breastfeeding should be discontinued if essential
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Information for patients regarding capsule consumption and use of antacids
- No safety and effectiveness established in paediatric patients; No overall differences in safety and efficacy observed in the elderly
Use in Special Populations
- Safety and effectiveness not established in paediatric patients
- No overall differences in safety and efficacy observed in the elderly
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency; Restricted dose for severe hepatic insufficiency; No alteration in pharmacokinetics in patients with renal impairment
Overdose Effects
Signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions; No specific antidote known; Symptomatic and supportive treatment recommended
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place; Protect from light and moisture; Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg
Common Questions about Esofour 40 mg Tablet
- Function as a proton pump inhibitor
- Used for treating gastroesophageal reflux disease (GERD), ulcers, and conditions involving excessive stomach acid
- Common side effects include headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth
- Safety concerns during pregnancy and breastfeeding
- Starts to work within a few hours of consumption