Flutinex 50 mg/5 ml (Powder for Suspension)

35 ml bottle: ৳ 78.24

Medicine Details

Category Details
Generic Fluconazole
Company Novatek pharmaceuticals ltd
Also available as
Flutinex 50 mg capsule Flutinex 150 mg capsule

Title, Categories, and Description

  • Product Title: Flutinex
  • Categories:
    • Medicine
    • Antifungal
    • Therapeutic Drugs
  • Description: Flutinex is an antifungal medicine indicated for treating various fungal infections, including vaginal candidiasis, oropharyngeal candidiasis, tinea, pityriasis versicolor, onychomycosis, and invasive candidal infections. It is a triazole antifungal agent that inhibits fungal cytochrome P-450 dependent enzymes, essential for fungal cell membrane synthesis.

Dimensions and Dosage

  • Dosage Forms Available: Tablet, Intravenous Infusion
  • Dosage for Adults:
    • Vaginal Candidiasis: 150 mg single dose
    • Oropharyngeal Candidiasis: 200 mg first day, then 100 mg daily for 14 days
    • Tinea: 150 mg weekly for 4-6 weeks
    • Onychomycosis: 150 mg weekly for 12 months
    • Invasive Candidal Infections and Cryptococcal Infections: 400 mg on first day, then 200-400 mg daily
    • Prevention of Cryptococcal Meningitis: 200 mg daily
  • Dosage for Children (over 1 year):
    • In Superficial Candidiasis: 1-2 mg/kg daily
    • In Systemic Candidiasis & Cryptococcal infection: 3-6 mg/kg daily
  • Storage Conditions: Keep in a dry place away from light and heat. Keep out of the reach of children.

Medication Interaction and Precautions

  • Interaction with Other Medications:
    • Warfarin
    • Sulphonylureas
    • Hydrochlorothiazide
    • Phenytoin
    • Rifampicin
    • Combined Oral Contraceptives
    • Cyclosporin
    • Food
    • Cimetidine
    • Antacids
    • Theophylline
  • Contraindications: Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or related triazole compounds.
  • Side Effects:
    • Common:
      • Nausea
      • Abdominal discomfort
      • Diarrhoea
      • Flatulence
    • Rare:
      • Rash
      • Anaphylaxis
  • Pregnancy & Lactation: Fluconazole adverse fetal effects have been seen in animals only at dose levels associated with maternal toxicity. It should not be used in pregnancy or in women of childbearing potential unless adequate contraception is employed.

Special Populations and Overdose Effects

  • Use in the Elderly: The normal dose should be used if there is no evidence of renal impairment.
  • Use in Renal Impairment: No adjustments in single dose therapy are required. In multiple dose therapy, the dosage intervals or daily dosage should be modified in accordance with creatinine clearance.
  • Overdose Effects: Supportive measures and symptomatic treatment with gastric lavage if necessary may be adequate.

Pharmacology

  • Mode of Action: Fluconazole is a potent inhibitor of fungal cytochrome P-450 dependent enzymes, essential for fungal cell membrane synthesis.

Precautions and Warnings

  • Abnormalities in Biochemical Function Tests: Abnormalities have been observed in patients with serious underlying diseases such as AIDS and cancer; the clinical significance and relationship to treatment is uncertain.

Special Storage

  • Storage Conditions: Keep in a dry place away from light and heat. Keep out of the reach of children.

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