Lopo 50 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Losartan potassium |
| Company | Biopharma limited |
| Also available as |
Indications
- Hypertension
- Renal Protection in Type-2 Diabetic Patients with Proteinuria
Pharmacology
- Non-peptide orally active angiotensin II receptor blocker
- Binds to AT1 receptor in various tissues
- Reduces vasoconstriction and aldosterone release
Dosage & Administration
- Usual starting and maintenance dose of 50 mg once daily
- 25 mg twice daily if inadequate effect
- Total daily dose ranges from 25 mg to 100 mg
- Lower starting dose for patients over 75 years
Interaction
- Rifampicin and fluconazole reduce active metabolite levels
- Concomitant use with hydrochlorothiazide may potentiate effects
- Risk of increased serum potassium with potassium-sparing diuretics
- Attenuation of antihypertensive effect by indomethacin
- Increased risk of renal impairment with certain drug combinations
Contraindications
- Pregnant women
- Hypersensitivity to any component
- Concomitant use with Aliskiren in patients with diabetes
Side Effects
- Mild and transient side effects
- Common side effects include dizziness, diarrhea, nasal congestion, cough, and upper respiratory infection
- Other side effects include fatigue, edema, abdominal pain, chest pain, nausea, headache, and pharyngitis
Pregnancy & Lactation
- Pregnancy Category D
- Risk increases in second or third trimester
- Unknown excretion in human milk
- Consideration for discontinuing nursing or drug intake
Precautions & Warnings
- Reduced fetal renal function and increased morbidity and death in second and third trimesters
- Risk of symptomatic hypotension in intravascularly volume-depleted patients
- Significantly increased plasma concentration in cirrhotic patients
- Reported changes in renal function and renal failure in renal impaired patients
- Dosage adjustments for mild, moderate, and severe renal impairment
- Precautions for patients with intravascular volume depletion and hepatic impairment
Use in Special Populations
- No initial dosage adjustment for mild renal impairment
- Lower starting dose recommended for moderate to severe renal impairment or patients on dialysis
- Lower dose consideration for patients with hepatic impairment
- May be administered with or without food
- Contraindications, warnings, and drug interactions to be noted
Therapeutic Class
- Angiotensin-II receptor blocker
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children