Cibact 250 mg/5 ml (Powder for Suspension)

60 ml bottle: ৳ 100.00

Medicine Details

Category Details
Generic Ciprofloxacin
Company Euro pharma ltd
Also available as
Cibact 500 mg tablet Cibact 750 mg tablet

Title

  • Cibact 500mg Tablets

Categories

  • Medicine
  • Pharmaceutical
  • Antibacterial
  • Anti-infective

Description

  • Cibact 500mg Tablets is a synthetic quinolone anti-infective agent indicated for the treatment of various infections caused by susceptible organisms. It has a broad spectrum of activity against gram-negative and gram-positive bacteria including Pseudomonas aeruginosa, Enterobacteriaceae, and staphylococci. The bactericidal action of Cibact results from interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA. It is widely distributed into the body tissues and fluids, with concentrations obtained in serum, body tissues, and urine following administration.

DosageRangeAdults

100-750 mg twice daily

DosageRangeUrinaryTractInfections

250-500 mg twice daily

DosageRangeRespiratoryTractInfections

250-500 mg twice daily for upper and lower respiratory tract infections

DosageRangeGonorrhea

A single dose of 250 or 500 mg

DosageRangeOtherInfections

500-750 mg twice daily

DosageCysticFibrosis

750 mg twice daily for pseudomonal infections of the lower respiratory tract

RenalFunctionDosageAdjustment

May be achieved by reducing the total daily dose by half in patients with severe renal impairment

DosageDurationAcuteInfections

5 to 10 days with continued treatment for three days after disappearance of signs and symptoms

PediatricDosage

7.5-15 mg/kg/day divided into two doses

DurationOfTreatment

Depends upon the severity of infection, clinical response, and bacteriological findings

ExtendedReleaseTabletDosage

1000 mg once daily for three days in uncomplicated urinary tract infection

IVInfusionDosage

  • UrinaryTractInfection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days
  • LowerRespiratoryTractInfection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days
  • NosocomialPneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days
  • SkinAndSkinStructure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days
  • BoneAndJointInfection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6 weeks
  • Intraabdominal: Complicated: 400 mg 12 hourly for 7-14 days
  • AcuteSinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days
  • ChronicBacterialProstatitis: Mild/Moderate: 400 mg 12 hourly for 28 days

ModeOfAction

Interference with the enzyme DNA gyrase needed for the synthesis of bacterial DNA

InteractionAvoidance

  • Concurrent administration should be avoided with magnesium/aluminium antacids, sucralfate, or products containing calcium, iron, and zinc
  • Should not be taken concurrently with milk or dairy products

Contraindications

  • Hypersensitivity to Ciprofloxacin or other quinolones

SideEffects

  • GastrointestinalDisturbances:
    • Nausea
    • Diarrhoea
    • Vomiting
    • Dyspepsia
    • Abdominal pain
  • CentralNervousSystemDisturbances:
    • Headache
    • Dizziness
    • Tiredness
    • Confusion
    • Convulsion
  • HypersensitivityReactions:
    • Skin rash
    • Pruritus
    • Possible systemic reactions
  • OtherReactions:
    • Joint pain
    • Mild photosensitivity
    • Transient increase in liver enzymes

PregnancyAndLactation

  • Teratogenicity: As with other quinolones, Ciprofloxacin has been shown to cause arthropathy in immature animals
  • SecretionInMilk: Studies in rats have indicated that Ciprofloxacin is secreted in milk, administration to nursing mothers is not recommended

Warnings

  • Use with caution in patients with suspected or known CNS disorders
  • Liberally drink fluids
  • Avoid concurrent administration with certain antacids or dairy products

SpecialPopulations

Not a drug of first choice in pediatric population

OverdoseEffects

  • Seizures
  • Hallucinations
  • Confusion
  • Renal and hepatic impairment
  • Crystalluria
  • Haematuria
  • Reversible renal toxicity

TherapeuticClass

  • 4-Quinolone preparations
  • Anti-diarrhoeal Antimicrobial drugs

StorageConditions

Keep below 30°C, protected from light and moisture, and out of the reach of children

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