Cetaxone 2 gm/vial (IV Injection)

2 gm vial: ৳ 300.00

Medicine Details

Category Details
Generic Ceftriaxone sodium
Company Euro pharma ltd
Also available as
Cetaxone 1 gm injection

Indications

  • Lower respiratory tract infections
  • Acute Bacterial Otitis Media
  • Skin and skin structure infections
  • Urinary tract infections
  • Gonorrhea
  • Bacterial Septicemia
  • Bone and joint infections
  • Meningitis
  • Prevention of postoperative infections
  • Perioperative prophylaxis of infections associated with surgery

Pharmacology

Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It kills bacteria by interfering with the synthesis of the bacterial cell wall. Ceftriaxone has a high degree of stability in the presence of beta lactamases. It has a relatively long plasma elimination half-life of about 6 to 9 hours, making single or once-daily dosage appropriate for most patients.

Dosage

  • Adult:
    • 1 to 2 gm IV or IM once a day (or in equally divided doses twice a day)
    • Maximum dose: 4 gm/day
    • Uncomplicated gonococcal infections: 250 mg IM as a single dose
    • Surgical prophylaxis: 1 g IV as a single dose 30 to 120 minutes before surgery
  • Infants and Children:
    • 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day)
    • Maximum dose: 2 gm/day for certain infections
    • Duration of therapy: 4 to 14 days; longer therapy may be required for complicated infections

Administration

  • Injection should be administered over 2-4 minutes by IM or IV injection or by tubing infusion over a period of 30 minutes
  • Before starting treatment, patient tolerance test should be checked by administration of a test dose
  • The use of freshly reconstituted solution is recommended

Interaction

No drug interactions reported

Contraindications

Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics

Side Effects

  • Gastro-intestinal effects including diarrhea, nausea, and vomiting
  • Cutaneous reactions including rash, pruritus, urticaria
  • Hematologic reactions including eosinophilia, thrombocytopenia
  • Hepatic reactions including elevations of SGOT or SGPT
  • CNS reactions including nervousness, confusion, sleep disturbances
  • Local phlebitis occurs rarely following IV administration

Pregnancy & Lactation

Use not established in human pregnancy; caution during lactation

Precautions & Warnings

  • Anaphylactic shock cannot be ruled out
  • Shadows suggesting sludge have been detected by sonograms of the gallbladder; reversible on discontinuation or completion of therapy
  • Regular blood picture check during prolonged treatment

Use in Special Populations

Cetaxone must not be given to neonates if premature or newborn (up to 28 days of age)

Overdose Effects

No specific antidote; treatment should be symptomatic

Therapeutic Class

Third generation Cephalosporins

Storage Conditions

Vial store in a cool, dry place (below 30°C), away from light & moisture; Keep out of the reach of children

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