Sitaglap M 50 mg+1000 mg (Tablet)

Unit Price: ৳ 22.00 (2 x 10: ৳ 440.00)
Strip Price: ৳ 220.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Euro pharma ltd
Also available as
Sitaglap m 50 mg tablet

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Improves glycemic control in adults

Pharmacology

  • Combines sitagliptin and metformin
  • Dipeptidyl peptidase-4 (DPP-4) inhibitor
  • Biguanide class member
  • Mechanism of action on insulin and glucagon levels
  • Regulation of glucose homeostasis

Dosage & Administration

  • Individualized dosage
  • Maximum recommended daily dose
  • Twice daily administration
  • Gradual dose escalation
  • Incremental dosing for reduced side effects
  • Maintenance of combination therapy
  • Extended-release tablet dosing
  • Co-administration with insulin
  • Lower doses with other antihyperglycemic agents

Interaction

  • Cationic drugs caution
  • Phenprocoumon effect on anticoagulant
  • Levothyroxine effect on hypoglycemia

Contraindications

  • Renal disease or dysfunction
  • Metabolic acidosis
  • Hypersensitivity reaction
  • Use with iodinated contrast materials

Side Effects

  • Common adverse reactions
  • Hypoglycemia incidence
  • Hypoglycemia with insulin
  • Adverse reactions with monotherapy
  • Initiation adverse reactions of metformin therapy

Pregnancy & Lactation

  • Pregnancy category B
  • Use during pregnancy only if necessary
  • Caution in nursing women

Precautions & Warnings

  • Risk of lactic acidosis
  • Monitoring of TSH levels
  • Association with vitamin B12 level decrease
  • Hepatic disease caution
  • Renal function assessment
  • Acute pancreatitis risk
  • Hematologic parameter monitoring
  • Limitation of alcohol intake
  • Temporary insulin use during stress or decreased intake
  • Allergic and hypersensitivity reactions
  • No conclusive evidence of macrovascular risk reduction

Overdose Effects

  • Supportive measures for sitagliptin
  • Dialyzable nature of sitagliptin
  • Overdose occurrences with metformin hydrochloride
  • Dialyzable nature of metformin
  • Pancreatitis risk

Therapeutic Class

  • Combination oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C
  • Dry place away from light
  • Safety around children
  • Use before expiry date
  • Dispensed only on prescription

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