Esoflux 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Centeon pharma ltd
Also available as

Indications

  • Chronic heartburn relief
  • Erosive esophagitis healing
  • Maintenance of esophagitis healing
  • Eradication of Helicobacter pylori infection
  • Zollinger-Ellison Syndrome treatment
  • Acid-related Dyspepsia relief
  • Duodenal and Gastric ulcer healing

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Absorption: peak plasma levels at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolism: extensive metabolism in the liver
  • Excretion: plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • Oral dosage form for various conditions
  • IV Injection or IV infusion for different patient groups

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension preparation and administration
  • IV Injection preparation and administration

Interaction

  • Extensive metabolism by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain drugs
  • Potential interference with CYP2C19 and gastric pH dependent drugs
  • Specific interactions with oral contraceptives, diazepam, phenytoin, or quinidine
  • Increased plasma levels of Esoflux and 14-hydroxyclarithromycin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Frequently occurring adverse events: headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
  • No difference in types of related adverse events seen during maintenance treatment

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealing no teratogenic effects
  • Excretion of esomeprazole in milk not studied
  • Discontinuation of breastfeeding if esomeprazole use is considered essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific instructions for patients with difficulty swallowing capsules
  • Allowed use of antacids while taking Esoflux

Use in Special Populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy in the elderly
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Acute toxic signs include reduced motor activity, respiratory changes, tremor, ataxia, clonic convulsions
  • No specific antidote known, symptomatic and supportive treatment recommended

Storage Conditions

  • Temperature not exceeding 30°C
  • Dry place, protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Esoflux 40 mg Capsule

  • Proton pump inhibitor with multiple uses
  • Common side effects and their duration
  • Considerations for pregnant or breastfeeding individuals
  • Onset of action after ingestion
  • Quick tips for medication use

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