Avastrol 10 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Atorvastatin calcium
Company Centeon pharma ltd
Also available as
Avastrol 20 mg tablet

Product Title

  • Avastrol 10 mg Tablet

Categories

  • Medicine
  • Pharmaceutical

Description

  • Avastrol is indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various conditions.

Function

  • Reduces elevated total cholesterol
  • Lowers LDL cholesterol and apolipoprotein B levels
  • Reduces triglycerides levels
  • Prevents cardiac ischaemic events
  • Adjunct to diet for various dyslipidemias

Dosage & Administration

  • 10 mg or 20 mg once daily
  • Dosage may be adjusted according to patient response
  • Administration with or without food
  • Dose adjustment based on lipid levels within 2 to 4 weeks

Pharmacology

  • Selective inhibitor of HMG-CoA reductase
  • Lowers plasma cholesterol and lipoprotein levels
  • Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL

Absorption

  • Rapid absorption after oral administration
  • Maximum plasma concentrations occur within 1 to 2 hours

Distribution

  • Mean volume of distribution approximately 381 liters
  • 98% bound to plasma proteins

Metabolism

  • Extensively metabolized to ortho- and parahydroxylated derivatives and beta-oxidation products
  • Metabolism by cytochrome P450 3A4
  • Active metabolites contribute to circulating inhibitory activity for HMG-CoA reductase

Excretion

  • Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
  • Mean plasma elimination half-life approximately 14 hours

Interaction

  • Increased risk of myopathy with concurrent administration of specific drugs
  • Plasma concentration alterations with coadministration of antacid, colestipol, digoxin, erythromycin, oral contraceptives, warfarin

Contraindications

  • Hypersensitivity to any component of the medication
  • Active liver disease or unexplained persistent elevations of serum transaminases
  • History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

  • Constipation
  • Flatulence
  • Dyspepsia
  • Abdominal pain
  • Infection
  • Headache
  • Back pain
  • Rash
  • Asthenia
  • Arthralgia
  • Myalgia

Pregnancy & Lactation

  • Contraindicated during pregnancy
  • Not known if excreted in human milk
  • Potential for serious adverse reactions in breastfeeding women

Precautions & Warnings

  • Liver function tests should be performed before initiation of treatment and periodically thereafter
  • Caution in patients with substantial alcohol consumption or history of liver disease

Pediatric Uses

  • Plasma concentrations higher in healthy elderly subjects
  • Clinical data suggests greater LDL-lowering in elderly patients

Overdose Effects

  • No specific treatment available
  • Symptomatic and supportive measures recommended
  • Liver function tests and serum CK levels monitoring advised

Therapeutic Class

  • Other Anti-anginal & Anti-ischaemic drugs
  • Statins

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C33H35FN2O5
  • Chemical Structure Image: [link to chemical structure image]

Common Questions & Answers

  • What is Avastrol 10 mg Tablet?
  • How should I take Avastrol 10 mg Tablet?
  • What are the uses of Avastrol 10 mg Tablet?
  • What are the side effects of Avastrol 10 mg Tablet?
  • What are the instructions for storage and disposal of Avastrol 10 mg Tablet?
  • Is Avastrol 10 mg Tablet used for lowering cholesterol?
  • Will taking Avastrol 10 mg Tablet increase my risk of diabetes?
  • For how long do I need to take Avastrol 10 mg Tablet? Is it safe for long-term use?
  • Does Avastrol 10 mg Tablet cause weight loss?
  • Can I stop taking Avastrol 10 mg Tablet?
  • Does Avastrol 10 mg Tablet cause memory loss?
  • Does Avastrol 10 mg Tablet make you tired?
  • Can Avastrol 10 mg Tablet be prescribed to children?
  • Is Avastrol 10 mg Tablet a blood thinner?
  • Quick Tips

Indications

  • Reduction of total cholesterol and LDL cholesterol in familial hypercholesterolaemia
  • Treatment of mixed dyslipidemia and hypertriglyceridemia
  • Reduction of cardiac ischaemic events in patients with coronary artery disease

Mode of Action

  • Inhibition of HMG-CoA reductase
  • Enhanced hepatic LDL uptake and catabolism

Drug Classes

  • Selective inhibitor of HMG-CoA reductase
  • Statins

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